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SOS 系统：对 DNA 损伤的复杂且严格调控的反应。

The SOS system: A complex and tightly regulated response to DNA damage.

作者信息

Maslowska Katarzyna H, Makiela-Dzbenska Karolina, Fijalkowska Iwona J

机构信息

Cancer Research Center of Marseille, CNRS, UMR7258, Inserm, U1068; Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France.

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.

出版信息

Environ Mol Mutagen. 2019 May;60(4):368-384. doi: 10.1002/em.22267. Epub 2019 Jan 7.

DOI:10.1002/em.22267
PMID:30447030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6590174/
Abstract

Genomes of all living organisms are constantly threatened by endogenous and exogenous agents that challenge the chemical integrity of DNA. Most bacteria have evolved a coordinated response to DNA damage. In Escherichia coli, this inducible system is termed the SOS response. The SOS global regulatory network consists of multiple factors promoting the integrity of DNA as well as error-prone factors allowing for survival and continuous replication upon extensive DNA damage at the cost of elevated mutagenesis. Due to its mutagenic potential, the SOS response is subject to elaborate regulatory control involving not only transcriptional derepression, but also post-translational activation, and inhibition. This review summarizes current knowledge about the molecular mechanism of the SOS response induction and progression and its consequences for genome stability. Environ. Mol. Mutagen. 60:368-384, 2019. © 2018 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society.

摘要

所有生物的基因组都不断受到内源性和外源性因素的威胁，这些因素会挑战DNA的化学完整性。大多数细菌已经进化出对DNA损伤的协同反应。在大肠杆菌中，这种可诱导系统被称为SOS反应。SOS全局调控网络由多种促进DNA完整性的因子以及易出错因子组成，这些易出错因子允许在广泛的DNA损伤情况下以提高诱变率为代价实现存活和持续复制。由于其诱变潜力，SOS反应受到精细的调控，不仅涉及转录去阻遏，还涉及翻译后激活和抑制。本综述总结了关于SOS反应诱导和进展的分子机制及其对基因组稳定性影响的当前知识。《环境与分子诱变》2019年第60卷：368 - 384页。© 2018作者。由Wiley Periodicals, Inc.代表环境诱变学会出版的《环境与分子诱变》。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c3/6590174/4c681d740fa4/EM-60-368-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c3/6590174/1d2ca30ba7fd/EM-60-368-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c3/6590174/4c681d740fa4/EM-60-368-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c3/6590174/1d2ca30ba7fd/EM-60-368-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82c3/6590174/4c681d740fa4/EM-60-368-g002.jpg

相似文献

[1]
The SOS system: A complex and tightly regulated response to DNA damage.

Environ Mol Mutagen. 2019-5

[2]
Non-canonical LexA proteins regulate the SOS response in the Bacteroidetes.

Nucleic Acids Res. 2021-11-8

[3]
ImuB and ImuC contribute to UV-induced mutagenesis as part of the SOS regulon in Pseudomonas aeruginosa.

Environ Mol Mutagen. 2019-4-30

[4]
The SOS response: recent insights into umuDC-dependent mutagenesis and DNA damage tolerance.

Annu Rev Genet. 2000

[5]
UmuDAb: An Error-Prone Polymerase Accessory Homolog Whose N-Terminal Domain Is Required for Repression of DNA Damage Inducible Gene Expression in Acinetobacter baylyi.

PLoS One. 2016-3-24

[6]
SOS-regulated proteins in translesion DNA synthesis and mutagenesis.

Trends Biochem Sci. 1995-10

[7]
Mutagenesis and more: umuDC and the Escherichia coli SOS response.

Genetics. 1998-4

[8]
Induction of the SOS regulon of Haemophilus influenzae does not affect phase variation rates at tetranucleotide or dinucleotide repeats.

Microbiology (Reading). 2005-8

[9]
Mutations for Worse or Better: Low-Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly Regulated Double-Edged Sword.

Biochemistry. 2016-4-26

[10]
Effect of mismatch repair on the mutational footprint of the bacterial SOS mutator activity.

DNA Repair (Amst). 2021-7

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本文引用的文献

[1]
Specialised DNA polymerases in Escherichia coli: roles within multiple pathways.

Curr Genet. 2018-12

[2]
Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism.

Annu Rev Biochem. 2018-3-1

[3]
DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli.

PLoS Genet. 2018-1-19

[4]
Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis.

Elife. 2017-12-6

[5]
Collision with duplex DNA renders Escherichia coli DNA polymerase III holoenzyme susceptible to DNA polymerase IV-mediated polymerase switching on the sliding clamp.

Sci Rep. 2017-10-16

[6]
Blocking the RecA activity and SOS-response in bacteria with a short α-helical peptide.

Nucleic Acids Res. 2017-9-19

[7]
A Small-Molecule Inducible Synthetic Circuit for Control of the SOS Gene Network without DNA Damage.

ACS Synth Biol. 2017-11-17

[8]
Identification of the Dimer Exchange Interface of the Bacterial DNA Damage Response Protein UmuD.

Biochemistry. 2017-9-12

[9]
The SOS and RpoS Regulons Contribute to Bacterial Cell Robustness to Genotoxic Stress by Synergistically Regulating DNA Polymerase Pol II.

Genetics. 2017-7

[10]
RNA Primer Extension Hinders DNA Synthesis by Mutagenic DNA Polymerase IV.

Front Microbiol. 2017-3-1

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