Maslowska Katarzyna H, Makiela-Dzbenska Karolina, Fijalkowska Iwona J
Cancer Research Center of Marseille, CNRS, UMR7258, Inserm, U1068; Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France.
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Environ Mol Mutagen. 2019 May;60(4):368-384. doi: 10.1002/em.22267. Epub 2019 Jan 7.
Genomes of all living organisms are constantly threatened by endogenous and exogenous agents that challenge the chemical integrity of DNA. Most bacteria have evolved a coordinated response to DNA damage. In Escherichia coli, this inducible system is termed the SOS response. The SOS global regulatory network consists of multiple factors promoting the integrity of DNA as well as error-prone factors allowing for survival and continuous replication upon extensive DNA damage at the cost of elevated mutagenesis. Due to its mutagenic potential, the SOS response is subject to elaborate regulatory control involving not only transcriptional derepression, but also post-translational activation, and inhibition. This review summarizes current knowledge about the molecular mechanism of the SOS response induction and progression and its consequences for genome stability. Environ. Mol. Mutagen. 60:368-384, 2019. © 2018 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society.
所有生物的基因组都不断受到内源性和外源性因素的威胁，这些因素会挑战DNA的化学完整性。大多数细菌已经进化出对DNA损伤的协同反应。在大肠杆菌中，这种可诱导系统被称为SOS反应。SOS全局调控网络由多种促进DNA完整性的因子以及易出错因子组成，这些易出错因子允许在广泛的DNA损伤情况下以提高诱变率为代价实现存活和持续复制。由于其诱变潜力，SOS反应受到精细的调控，不仅涉及转录去阻遏，还涉及翻译后激活和抑制。本综述总结了关于SOS反应诱导和进展的分子机制及其对基因组稳定性影响的当前知识。《环境与分子诱变》2019年第60卷：368 - 384页。© 2018作者。由Wiley Periodicals, Inc.代表环境诱变学会出版的《环境与分子诱变》。
