Yaghoobi Mojtaba Hedayat, Taher Abbas, Seifrabie Mohamad Ali, Sabahi Mohammadmahdi, Rahimi-Bashar Farshid
Department of Infectious Disease, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Department of Anesthesiology and Critical Care, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Rom J Intern Med. 2019 Mar 1;57(1):55-60. doi: 10.2478/rjim-2018-0033.
Vitamin D deficiency is considered one of the most common nutritional deficiencies associated with weakened immune system and increased likelihood of sepsis. The current study was conducted to investigate the association between serum vitamin D level and the severity and prognosis of ventilator associated pneumonia (VAP) in inpatients in intensive care unit (ICU).
Eighty-four consecutive patients with VAP were enrolled in this observational, prospective study conducted in the ICU of Besat Hospital, Hamadan. The patients were examined for serum 25-hydroxyvitamin D (vitD3) level and VAP severity and prognosis. Clinical pulmonary infection score was used for the diagnosis, and Sequential Organ Failure Assessment (SOFA) Score was used to determine the severity of VAP.
Low level serum vitD3 (under 30 ng/mL) was found in 66 (78.6%) patients. In this series of VAP patients, there were no significant differences in blood culture results, 14 and 28-day sepsis-associated mortality, mechanical ventilation duration, or SOFA Score on days 3, 7, and 14 between the low level and normal level vitD3 patients (p > 0.05).
Serum vitD3 level was not associated with mortality from VAP or complications due to sepsis in the inpatients in the ICU.
维生素D缺乏被认为是最常见的营养缺乏症之一，与免疫系统减弱及脓毒症发生可能性增加有关。本研究旨在调查重症监护病房（ICU）住院患者血清维生素D水平与呼吸机相关性肺炎（VAP）严重程度及预后之间的关联。
在哈马丹省贝萨特医院ICU进行的这项观察性前瞻性研究中，连续纳入了84例VAP患者。对患者进行血清25-羟基维生素D（vitD3）水平、VAP严重程度及预后检查。采用临床肺部感染评分进行诊断，序贯器官衰竭评估（SOFA）评分用于确定VAP的严重程度。
66例（78.6%）患者血清vitD3水平较低（低于30 ng/mL）。在这组VAP患者中，vitD3水平低的患者与正常水平的患者在血培养结果、14天和28天脓毒症相关死亡率、机械通气时间或第3、7和14天的SOFA评分方面无显著差异（p>0.05）。
ICU住院患者血清vitD3水平与VAP死亡率或脓毒症并发症无关。
