UTA-RAM-OneHealth Group, Centro de Investigaciones Agropecuarias, Facultad de Ciencias Agropecuarias, Universidad Técnica de Ambato, Tungurahua, Ecuador.
Catalan Institute for Water Research (ICRA), University of Girona, Girona, Spain.
Sci Total Environ. 2019 Mar 1;654:452-455. doi: 10.1016/j.scitotenv.2018.11.166. Epub 2018 Nov 12.
Although antibiotic resistance represents a significant and growing threat to human and environmental health worldwide, the contribution of bacteriophages (phages) to the acquisition and spread of antibiotic resistance genes (ARGs) in the environment has not been extensively explored. In this study, a comprehensive analysis of several viromes from diverse marine habitats was performed to investigate whether or not phages carry ARGs. The analysis provides strong evidence that phages from marine habitats are potential reservoirs of ARGs. In fact, genes conferring resistance to aminocoumarin, bacitracin and multidrug resistance (particularly the mexB gene) were found in all analyzed marine viromes. Given this, the role of phages as reservoirs of ARGs should not be underestimated considering their global distribution.
尽管抗生素耐药性对全球人类和环境健康构成了重大且日益严重的威胁，但噬菌体（phages）在环境中获取和传播抗生素耐药基因（ARGs）方面的作用尚未得到广泛探索。在这项研究中，对来自不同海洋生境的多个病毒组进行了全面分析，以研究噬菌体是否携带 ARGs。分析结果提供了有力的证据，表明海洋生境中的噬菌体是 ARGs 的潜在储存库。事实上，所有分析的海洋病毒组中都发现了赋予氨基香豆素、杆菌肽和多药耐药性（特别是 mexB 基因）的基因。鉴于此，考虑到噬菌体的全球分布，它们作为 ARGs 储存库的作用不应被低估。
