通过溶解氧调节和添加粗甘油从油脂酵母（Trichosporon oleaginosus）生产经济的油脂。
Economical lipid production from Trichosporon oleaginosus via dissolved oxygen adjustment and crude glycerol addition.
机构信息
Department of Civil and Environmental Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong 518055, PR China.
Department of Civil and Environmental Engineering, Chinese National Engineering Research Center for Control and Treatment of Heavy Metal Pollution, and Water Technology Center, The Hong Kong University of Science and Technology, Hong Kong.
出版信息
Bioresour Technol. 2019 Feb;273:288-296. doi: 10.1016/j.biortech.2018.11.033. Epub 2018 Nov 10.
The effect of dissolved oxygen concentration on lipid accumulation in Trichosporon oleaginosus has been investigated. The experiment was performed in 15 L fermenters. The dissolved oxygen concentration varied by adjusting the agitation and aeration. High dissolved oxygen level at 50%-60% enhanced cell growth. Maintaining low dissolved oxygen concentration at 20%-30% during lipogenesis phase led to high final lipid content (51%) in Trichosporon oleaginosus. The consumptions of energy and cost of the process were evaluated. The energy consumption in the dissolved oxygen level optimized process was 41% less than that with dissolved oxygen level at 50%-60%. In addition, the cost was also reduced around one time in the dissolved oxygen level optimized process compared to the one with dissolved oxygen level at 50%-60%. The study provided a feasible way of enhancing lipid accumulation in Trichosporon oleaginosus and reducing the consumption of energy and cost of lipid production from Trichosporon oleaginosus.
研究了溶解氧浓度对油脂酵母（Trichosporon oleaginosus）脂肪积累的影响。实验在 15L 发酵罐中进行。通过调节搅拌和通气来改变溶解氧浓度。高溶解氧水平（50%-60%）促进细胞生长。在产脂阶段保持低溶解氧浓度（20%-30%）可导致油脂酵母（Trichosporon oleaginosus）中最终脂质含量（51%）升高。评估了能量消耗和过程成本。在优化溶解氧水平的过程中，能量消耗比溶解氧水平为 50%-60%时减少了 41%。此外，与溶解氧水平为 50%-60%相比，在优化溶解氧水平的过程中成本也降低了约 1 倍。该研究为提高油脂酵母（Trichosporon oleaginosus）中脂质的积累，降低从油脂酵母（Trichosporon oleaginosus）生产脂质的能量消耗和成本提供了一种可行的方法。
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