紫花苜蓿三萜皂苷对 HO 诱导的 SH-SY5Y 细胞氧化应激的神经保护作用。
Neuroprotective effects of triterpenoid saponins from Medicago sativa L. against HO-induced oxidative stress in SH-SY5Y cells.
机构信息
College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China; Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China.
College of Pharmaceutical and Biological Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning 110142, People's Republic of China.
出版信息
Bioorg Chem. 2019 Mar;83:468-476. doi: 10.1016/j.bioorg.2018.11.008. Epub 2018 Nov 13.
Medicago sativa L. is a forage legume plant widely distributed in all continents. Six new triterpenoid saponins, Medicagosides A-F (1-6) and five known ones (7-11) were isolated from M. sativa. Their structures were determined via HRESIMS, 1D and 2D NMR analysis. Biologically, all the isolates displayed neuroprotective activities against HO-induced damage in SH-SY5Y cells. Among them, compounds 1, 3-5 and 10 exhibited striking neuroprotective activities at 100 μM, restoring cell viability range from 79.66% to 89.03%, relative to 79.46% (100 μM) of Trolox used as the positive control.
紫花苜蓿是一种广泛分布于各大洲的饲料豆科植物。从紫花苜蓿中分离得到了六种新的三萜皂苷，即 Medicagosides A-F（1-6）和五种已知的皂苷（7-11）。通过 HRESIMS、1D 和 2D NMR 分析确定了它们的结构。在生物学方面，所有分离物均显示出对 HO 诱导的 SH-SY5Y 细胞损伤的神经保护活性。其中，化合物 1、3-5 和 10 在 100µM 时表现出显著的神经保护活性，相对于 Trolox（阳性对照，100µM）的细胞活力恢复率为 79.66%至 89.03%。
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