原卟啉 IX 作为光敏剂被二氧化硅纳米颗粒包裹的光动力应用。
Photodynamic application of protoporphyrin IX as a photosensitizer encapsulated by silica nanoparticles.
机构信息
a Al Ghad international College for Medical Sciences , Riyadh , Saudi Arabia.
b School of Physics , Universiti Sains Malaysia , Penang , Malaysia.
出版信息
Artif Cells Nanomed Biotechnol. 2018;46(sup3):S1043-S1046. doi: 10.1080/21691401.2018.1528982. Epub 2018 Nov 19.
BACKGROUND
Achieved Silica Nanoparticles (SiNPs) to encapsulate the photosensitizer [Protoporphyrin IX (PpIX)] in photodynamic therapy (PDT) application was reported in this research.
MATERIALS AND METHODS
Cytotoxicity for five different concentrations of encapsulated and naked PpIX was measured. Optimum concentration and optimum exposure time of encapsulated and naked PpIX that needed to destroy the cells (Osteosarcoma cells) was measured.
RESULTS
The results showed that the encapsulated PpIX has more efficacy compared to the naked PpIX and the applicability of the encapsulated PpIX-SiNPs was proved on osteosarcoma cells.
CONCLUSION
The results established the important in-vitro photodynamic effectiveness of PpIX-SiNP, which may open a new application for PpIX in its clinical and in-vitro studies.
背景
本研究报告了用硅纳米颗粒（SiNPs）包裹光敏剂[原卟啉 IX（PpIX）]在光动力疗法（PDT）中的应用。
材料与方法
测量了五种不同浓度包裹和裸露 PpIX 的细胞毒性。测量了破坏细胞（骨肉瘤细胞）所需的最佳浓度和最佳暴露时间的包裹和裸露 PpIX。
结果
结果表明，与裸露的 PpIX 相比，包裹的 PpIX 具有更好的疗效，并且已经证明包裹的 PpIX-SiNPs 在骨肉瘤细胞上具有适用性。
结论
该结果确立了 PpIX-SiNP 在体外的重要光动力疗效，这可能为 PpIX 在其临床和体外研究中开辟新的应用。
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