Division of Cardiovascular Medicine, Department of Medicine, The Ohio State University, 473 W 12th Avenue, DHLRI Suite 200, Columbus, Ohio 43210, USA.
Division of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City, UT, USA.
Heart Fail Clin. 2019 Jan;15(1):137-145. doi: 10.1016/j.hfc.2018.08.013. Epub 2018 Oct 24.
Prevalence of pulmonary arterial hypertension (PAH) is higher in women, and the mechanism remains unclear. Prognosis is overall better for female compared with male patients with PAH. Pregnancy is associated with significant risk, mortality, and morbidity in patients with PAH; consensus guidelines recommend against pregnancy and counsel about early termination in these patients. Recent advances in treatment showed improvement in prognosis in small case reports of pregnant patients with PAH, particularly with the early use of parental prostacyclin. Education remains fundamental for women with PAH of childbearing age for pregnancy prevention as well as discussion about birth control methods.
肺动脉高压（PAH）在女性中的患病率较高，其机制尚不清楚。与男性 PAH 患者相比，女性患者的总体预后较好。妊娠会使 PAH 患者面临重大风险、死亡和发病；共识指南建议这些患者避免妊娠并考虑早期终止妊娠。最近的治疗进展显示，在小病例报告中，妊娠 PAH 患者的预后有所改善，特别是在早期使用双亲前列环素时。对于育龄期患有 PAH 的女性，教育仍然是预防妊娠以及讨论避孕方法的基础。
