螯合控制的酯衍生烯醇钛醛醇缩合反应：与单齿和双齿醛的非对映选择性醛醇缩合反应
Chelation-controlled ester-derived titanium enolate aldol reaction: diastereoselective -aldols with mono- and bidentate aldehydes.
作者信息
Ghosh Arun K, Kim Jae-Hun
机构信息
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, IL 60607, USA.
出版信息
Tetrahedron Lett. 2002 Aug 5;43(32):5621-5624. doi: 10.1016/S0040-4039(02)01113-9. Epub 2002 Jul 17.
Abstract
A chelation-controlled and highly diastereoselective synthesis of -aldols is described. Aldol reaction of ()-valinol-derived ester with a variety of aldehydes proceeded with high -diastereoselectivities (up to 99:1) and isolated yields (94%).
摘要
描述了一种螯合控制且具有高度非对映选择性的α-醇醛的合成方法。（S）-缬氨醇衍生的酯与多种醛的醇醛反应以高非对映选择性（高达99:1）和分离产率（94%）进行。
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本文引用的文献
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2
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3
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