胶质母细胞瘤中的T细胞耗竭 - Suppr

T-cell exhaustion in glioblastoma.

作者信息

Woroniecka Karolina, Fecci Peter E

机构信息

Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA; Department of Pathology, Duke University Medical Center, Durham, NC, USA.

出版信息

Oncotarget. 2018 Oct 19;9(82):35287-35288. doi: 10.18632/oncotarget.26228.

DOI:10.18632/oncotarget.26228

PMID:30450155

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6219672/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97bc/6219672/8a1961761b35/oncotarget-09-35287-g001.jpg

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T-cell exhaustion in glioblastoma.胶质母细胞瘤中的T细胞耗竭

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本文引用的文献

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors.在脑胶质瘤和其他颅内肿瘤的情况下，T 细胞在骨髓中的隔离。

Nat Med. 2018 Sep;24(9):1459-1468. doi: 10.1038/s41591-018-0135-2. Epub 2018 Aug 13.

T-cell Dysfunction in Glioblastoma: Applying a New Framework.胶质母细胞瘤中的 T 细胞功能障碍：应用新框架。

Clin Cancer Res. 2018 Aug 15;24(16):3792-3802. doi: 10.1158/1078-0432.CCR-18-0047. Epub 2018 Mar 28.

T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma.T 细胞耗竭特征随肿瘤类型而变化，在神经胶质瘤中较为严重。

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Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.对治疗性程序性死亡蛋白1（PD-1）阻断的适应性耐药与其他免疫检查点的上调相关。

Nat Commun. 2016 Feb 17;7:10501. doi: 10.1038/ncomms10501.

Immunotherapy for primary brain tumors: no longer a matter of privilege.原发性脑肿瘤的免疫疗法：不再是特权问题。

Clin Cancer Res. 2014 Nov 15;20(22):5620-9. doi: 10.1158/1078-0432.CCR-14-0832.

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Neuro Oncol. 2006 Jul;8(3):234-43. doi: 10.1215/15228517-2006-006. Epub 2006 May 24.

Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma.在CD4细胞群减少的情况下，调节性T细胞比例增加，这解释了恶性胶质瘤患者的细胞免疫缺陷。

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Immune defects observed in patients with primary malignant brain tumors.原发性恶性脑肿瘤患者中观察到的免疫缺陷。

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Cytokinetic basis for the impaired activation of lymphocytes from patients with primary intracranial tumors.原发性颅内肿瘤患者淋巴细胞激活受损的细胞动力学基础。

J Immunol. 1984 Mar;132(3):1208-15.

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T-cell exhaustion in glioblastoma.

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