Mazarati Andrey, Jones Nigel C, Galanopoulou Aristea S, Harte-Hargrove Lauren C, Kalynchuk Lisa E, Lenck-Santini Pierre-Pascal, Medel-Matus Jesús-Servando, Nehlig Astrid, de la Prida Liset Menendez, Sarkisova Karine, Veliskova Jana
Department of Pediatrics David Geffen School of Medicine at UCLA Los Angeles California U.S.A.
UCLA Children's Discovery and Innovation Institute Los Angeles California U.S.A.
Epilepsia Open. 2018 Jul 18;3(Suppl Suppl 1):24-52. doi: 10.1002/epi4.12236. eCollection 2018 Nov.
The provided companion has been developed by the Behavioral Working Group of the Joint Translational Task Force of the International League Against Epilepsy (ILAE) and the American Epilepsy Society (AES) with the purpose of assisting the implementation of Preclinical Common Data Elements (CDE) for studying and for reporting neurobehavioral comorbidities in rodent models of epilepsy. Case Report Forms (CRFs) are provided, which should be completed on a per animal/per test basis, whereas the CDEs are a compiled list of the elements that should be reported. This companion is not designed as a list of recommendations, or guidelines for how the tests should be run-rather, it describes the different types of assessments, and highlights the importance of rigorous data collection and transparency in this regard. The tests are divided into 7 categories for examining behavioral dysfunction on the syndrome level: deficits in learning and memory; depression; anxiety; autism; attention deficit/hyperactivity disorder; psychosis; and aggression. Correspondence and integration of these categories into the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) is introduced. Developmental aspects are addressed through the introduction of developmental milestones. Discussion includes complexities, limitations, and biases associated with neurobehavioral testing, especially when performed in animals with epilepsy, as well as the importance of rigorous data collection and of transparent reporting. This represents, to our knowledge, the first such resource dedicated to preclinical CDEs for behavioral testing of rodents.
本配套资料由国际抗癫痫联盟（ILAE）和美国癫痫协会（AES）联合翻译工作组行为学工作小组编制，旨在协助实施临床前通用数据元素（CDE），以研究和报告癫痫啮齿动物模型中的神经行为共病。提供了病例报告表（CRF），应按每只动物/每次测试填写，而CDE是应报告元素的汇总列表。本配套资料并非设计为关于如何进行测试的建议列表或指南，而是描述了不同类型的评估，并强调了在这方面严格数据收集和透明度的重要性。这些测试分为7类，用于在综合征层面检查行为功能障碍：学习和记忆缺陷；抑郁；焦虑；自闭症；注意力缺陷/多动障碍；精神病；以及攻击性。介绍了这些类别与美国国立精神卫生研究所（NIMH）研究领域标准（RDoC）的对应和整合。通过引入发育里程碑来探讨发育方面。讨论内容包括与神经行为测试相关的复杂性、局限性和偏差，尤其是在癫痫动物中进行测试时，以及严格数据收集和透明报告的重要性。据我们所知，这是第一份专门用于啮齿动物行为测试临床前CDE的此类资源。
