Foster Mitchell T, Carleton-Bland Nicholas P, Lee Maggie K, Jackson Richard, Clark Simon R, Wilby Martin J
a Department of Neurosurgery , The Walton Centre NHS Foundation Trust , Liverpool , UK.
b Cancer Research UK Liverpool Cancer Trials Unit , University of Liverpool , Liverpool , UK.
Br J Neurosurg. 2019 Feb;33(1):3-7. doi: 10.1080/02688697.2018.1527013. Epub 2018 Nov 19.
The choice between anterior cervical discectomy & fusion (ACD) or posterior cervical foraminotomy (PCF) for the treatment of cervical brachialgia is controversial. This study aimes to compare clinical outcomes between these two operative inteventions for brachialgia.
Retrospective review of prospectively collected data was performed. Patients receiving a primary ACD or PCF to treat brachialgia, in a single tertiary neurosurgical unit were included. Surgical details, and patient reported outcomes (COMI-Neck questionnaire) were extracted from a prospectively maintained spinal procedure database. Minimum clinically important difference (MCID) was defined as a change in COMI score of -2 at 12 months. The student t-test, Chi-square test, and linear regression were used to compare groups.
Between June 2011 ad February 2016 there were 634 ACD procedures (Median age 49; 321 Male), and 54 PCF procedures (Median age 50; 37 Male) perfomed for brachialgia. Age, ASA and pre-operative COMI were similar between the groups (p > .05). Complete outcome data was recorded at twelve months in 312 ACD and 36 PCF patients. Both ACD and PCF were associated with an improvement in COMI at 3 and 12 months (all p < .01). Mean change in COMI at 3 months was -2.38 for ACD, versus -2.31 for PCF (p = .88); at twelve months it was -2.94 for ACD, versus -2.67 for PCF (p = .55). MCID was seen in 59% of ACD cases, versus 58% of PCF cases at twelve months (p = .91).
There was no significant difference between outcomes in the ACD and PCF groups. This is supportive of published literature. The proposed multicenter RCTs may inform further.
对于治疗颈臂痛,颈椎前路椎间盘切除融合术(ACD)与颈椎后路椎间孔切开术(PCF)之间的选择存在争议。本研究旨在比较这两种手术干预治疗臂丛神经痛的临床疗效。
对前瞻性收集的数据进行回顾性分析。纳入在单一三级神经外科单位接受初次ACD或PCF治疗臂丛神经痛的患者。从前瞻性维护的脊柱手术数据库中提取手术细节和患者报告的结果(COMI-颈部问卷)。最小临床重要差异(MCID)定义为12个月时COMI评分变化-2。采用学生t检验、卡方检验和线性回归比较组间差异。
2011年6月至2016年2月期间,共进行了634例ACD手术(中位年龄49岁;男性321例)和54例PCF手术(中位年龄50岁;男性37例)用于治疗臂丛神经痛。两组间年龄、美国麻醉医师协会(ASA)分级和术前COMI相似(p>0.05)。312例ACD患者和36例PCF患者在12个月时记录了完整的结局数据。ACD和PCF在3个月和12个月时均与COMI改善相关(所有p<0.01)。ACD组3个月时COMI的平均变化为-2.38,PCF组为- .31(p = 0.88);12个月时,ACD组为-2.94,PCF组为-2.67(p = 0.55)。12个月时,59%的ACD病例和58%的PCF病例出现MCID(p = 0.91)。
ACD组和PCF组的结局无显著差异。这支持了已发表的文献。拟议的多中心随机对照试验可能会提供更多信息。