Trang Do Thi, Huyen Le Thi, Nhiem Nguyen Xuan, Quang Tran Hong, Hang Dan Thi Thuy, Yen Pham Hai, Tai Bui Huu, Anha Hoang Le Tuan, Binh Nguyen Quoc, Van Minha Chau, Van Kiem Phan
Nat Prod Commun. 2016 Jul;11(7):935-937.
One new tirucallane-type triterpene glycoside, antidesoside (1), along with two biflavones, podocarpusflavone A (2) and amentoflavone (3) and two megastigmane glycosides, byzantionoside B (4), and (6S,9R)-roseoside (5) were isolated from the methanol extract of Antidesma bunius leaves. Their structures were determined by spectroscopic methods and in comparison with the published data. Compounds 1 - 3 were found to show strong inhibitory effect of NO production in BV2.cells and RAW264.7 macrophages LPS-stimulated, with IC₅₀ values ranging from 8.5 to 26.9 μM.
从五月茶树叶的甲醇提取物中分离出一种新的四环三萜糖苷——五月茶皂苷（1），以及两种双黄酮——罗汉松黄酮A（2）和穗花杉双黄酮（3），还有两种巨大戟烷糖苷——拜占庭糖苷B（4）和（6S，9R）-蔷薇糖苷（5）。通过光谱方法并与已发表的数据进行比较确定了它们的结构。发现化合物1 - 3对BV2细胞和RAW264.7巨噬细胞经脂多糖刺激产生的一氧化氮具有很强的抑制作用，IC₅₀值在8.5至26.9μM之间。
