Department of Cardiology, Skåne University Hospital, Lund University, SE-221 85 Lund, Sweden.
Department of Cardiology, Umeå University Hospital, SE-901 89, Umeå, Sweden.
Eur Heart J. 2019 Mar 7;40(10):820-830. doi: 10.1093/eurheartj/ehy709.
Catheter ablation is considered the treatment of choice for many tachyarrhythmias, but convincing 'real-world' data on efficacy and safety are lacking. Using Swedish national registry data, the ablation spectrum, procedural characteristics, as well as ablation efficacy and reported adverse events are reported.
Consecutive patients (≥18 years of age) undergoing catheter ablation in Sweden between 01 January 2006 and 31 December 2015 were included in the study. Follow-up (repeat ablation and vital status) was collected through 31 December 2016. A total of 26 642 patients (57 ± 15 years, 62% men), undergoing a total of 34 428 ablation procedures were included in the study. In total, 4034 accessory pathway/Wolff-Parkinson-White syndrome (12%), 7358 AV-nodal re-entrant tachycardia (21%), 1813 atrial tachycardia (5.2%), 5481 typical atrial flutter (16%), 11 916 atrial fibrillation (AF, 35%), 2415 AV-nodal (7.0%), 581 premature ventricular contraction (PVC, 1.7%), and 964 ventricular tachycardia (VT) ablations (2.8%) were performed. Median follow-up time was 4.7 years (interquartile range 2.7-7.0). The spectrum of treated arrhythmias changed over time, with a gradual increase in AF, VT, and PVC ablation (P < 0.001). Decreasing procedural times and utilization of fluoroscopy with time, were seen for all arrhythmia types. The rates of repeat ablation differed between ablation types, with the highest repeat ablation seen in AF (41% within 3 years). The rate of reported adverse events was low (n = 595, 1.7%). Death in the immediate period following ablation was rare (n = 116, 0.34%).
Catheter ablations have shifted towards more complex procedures over the past decade. Fluoroscopy time has markedly decreased and the efficacy of catheter ablation seems to improve for AF.
导管消融术被认为是许多快速性心律失常的首选治疗方法,但缺乏令人信服的“真实世界”疗效和安全性数据。本研究使用瑞典国家登记数据,报告消融谱、手术特点以及消融疗效和报告的不良事件。
本研究纳入了 2006 年 1 月 1 日至 2015 年 12 月 31 日期间在瑞典接受导管消融术的连续患者(年龄≥18 岁)。通过 2016 年 12 月 31 日收集随访(重复消融和生存状态)。共纳入 26642 例患者(57±15 岁,62%为男性),共行 34428 次消融术。共行 4034 例旁路/Wolff-Parkinson-White 综合征(12%)、7358 例房室结折返性心动过速(21%)、1813 例房性心动过速(5.2%)、5481 例典型心房扑动(16%)、11916 例心房颤动(AF,35%)、2415 例房室结(7.0%)、581 例室性早搏(PVC,1.7%)和 964 例室性心动过速(VT)消融术。中位随访时间为 4.7 年(四分位距 2.7-7.0)。随着时间的推移,治疗心律失常的范围发生了变化,AF、VT 和 PVC 消融术逐渐增加(P<0.001)。所有心律失常类型的手术时间和透视时间都随着时间的推移而减少。不同消融类型的重复消融率不同,AF 的重复消融率最高(3 年内为 41%)。报告的不良事件发生率较低(n=595,1.7%)。消融后即刻死亡罕见(n=116,0.34%)。
在过去十年中,导管消融术已转向更复杂的手术。透视时间显著减少,AF 的导管消融疗效似乎有所提高。