Center for Biochemical and Proteomics Analyses, Catholic University of Brasilia, Brasilia, Brazil.
Center for Protein Studies, Faculty of Biology, University of Havana, Cuba.
Int J Pharm. 2019 Jan 30;555:356-367. doi: 10.1016/j.ijpharm.2018.11.043. Epub 2018 Nov 16.
In the last years, the antimicrobial resistance against antibiotics has become a serious health issue, arise as global threat. This has generated a search for new strategies in the progress of new antimicrobial therapies. In this context, different nanosystems with antimicrobial properties have been studied. Specifically, magnetic nanoparticles seem to be very attractive due to their relatively simple synthesis, intrinsic antimicrobial activity, low toxicity and high versatility. Iron oxide NPs (IONPs) was authorized by the World Health Organization for human used in biomedical applications such as in vivo drug delivery systems, magnetic guided therapy and contrast agent for magnetic resonance imaging have been widely documented. Furthermore, the antimicrobial activity of different magnetic nanoparticles has recently been demonstrated. This review elucidates the recent progress of IONPs in drug delivery systems and focuses on the treatment of infectious diseases and target the possible detrimental biological effects and associated safety issues.
在过去的几年中，抗生素的抗药性已经成为一个严重的健康问题，是一个全球性的威胁。这促使人们寻求新的策略来开发新的抗菌疗法。在这方面，已经研究了具有抗菌特性的不同纳米系统。具体来说，由于其相对简单的合成、内在的抗菌活性、低毒性和高多功能性，磁性纳米粒子似乎非常有吸引力。氧化铁纳米粒子 (IONPs) 已被世界卫生组织授权用于人类的生物医学应用，如体内药物输送系统、磁性引导治疗和磁共振成像的对比剂，这已被广泛记录。此外，最近已经证明了不同磁性纳米粒子的抗菌活性。这篇综述阐述了 IONPs 在药物输送系统中的最新进展，并重点介绍了治疗传染病和靶向可能有害的生物效应以及相关安全问题。
