Faculty of Chemistry and Pharmacy, University of Sofia "St. Kl. Okhridski". J. Bourchier Blvd. 1, 1164 Sofia, Bulgaria.
Faculty of Chemistry and Pharmacy, University of Sofia "St. Kl. Okhridski". J. Bourchier Blvd. 1, 1164 Sofia, Bulgaria.
Adv Colloid Interface Sci. 2017 Nov;249:192-212. doi: 10.1016/j.cis.2017.05.003. Epub 2017 May 3.
The review presents a broad overview of the biomedical applications of surface functionalized iron oxide nanoparticles (IONPs) as magnetic resonance imaging (MRI) agents for sensitive and precise diagnosis tool and synergistic combination with other imaging modalities. Then, the recent progress in therapeutic applications, such as hyperthermia is discussed and the available toxicity data of magnetic nanoparticles concerning in vitro and in vivo biomedical applications are addressed. This review also presents the available computer models using molecular dynamics (MD), Monte Carlo (MC) and density functional theory (DFT), as a basis for a complete understanding of the behaviour and morphology of functionalized IONPs, for improving NPs surface design and expanding the potential applications in nanomedicine.
这篇综述广泛介绍了表面功能化氧化铁纳米粒子（IONPs）作为磁共振成像（MRI）造影剂在生物医学中的应用，将其作为一种敏感且精确的诊断工具，并与其他成像方式协同结合。然后，讨论了治疗应用的最新进展，如热疗，并讨论了关于体外和体内生物医学应用的磁性纳米粒子的可用毒性数据。这篇综述还介绍了使用分子动力学（MD）、蒙特卡罗（MC）和密度泛函理论（DFT）的可用计算机模型，作为深入了解功能化 IONPs 的行为和形态的基础，用于改进 NPs 表面设计并扩大在纳米医学中的潜在应用。
