Departamento de Física Aplicada and Instituto de Ciencia de Materiales Nicolás Cabrera, Universidad Autónoma de Madrid, Madrid, Spain.
Departamento de Física Aplicada and Instituto de Ciencia de Materiales Nicolás Cabrera, Universidad Autónoma de Madrid, Madrid, Spain; Centro de Microanálisis de Materiales, Universidad Autónoma de Madrid, Madrid, Spain.
Colloids Surf B Biointerfaces. 2019 Feb 1;174:174-180. doi: 10.1016/j.colsurfb.2018.11.010. Epub 2018 Nov 6.
The present work reports the processing of laser irradiated Si arrays (LISi) and underlines their surface enhanced Raman scattering (SERS) functionality. A nanostructured Si/SiO surface forms providing additional fluidic and photoprotective properties. Because of their optical and surface characteristics, the arrays exhibit a SERS analytical enhancing factor of 500, without any noble metals such as gold or silver. Micro-Raman maps allowed studying LISi properties, identifying maximum amplification in nanostructured areas characterized by the presence of 7 nm Si nanocrystals. These structures are confined by a SiO layer as illustrated by XPS valence band measurements. The highly hydrophilic LISi areas allow a pre-concentration of target molecules prior to SERS analysis. A relevant application of LISi was found in the detection of apomorphine (APO), a drug used for the treatment of Parkinson's disease. In contrast with what is obtained by using gold SERS substrates, LISi allows the detection of APO with no sign of oxidation. This invites for the use of the Si/SiOx SERS detection in future systems for the personalized delivery of APO.
本工作报道了激光辐照硅阵列（LISi）的处理，并强调了其表面增强拉曼散射（SERS）功能。形成了具有附加流体和光保护性能的纳米结构化 Si/SiO 表面。由于其光学和表面特性，该阵列表现出 500 的 SERS 分析增强因子，而无需使用金或银等贵金属。微拉曼图谱允许研究 LISi 的特性，确定在具有 7nm Si 纳米晶体的纳米结构化区域中的最大放大倍数。这些结构由 XPS 价带测量所示的 SiO 层限制。高亲水性 LISi 区域允许在 SERS 分析之前对目标分子进行预浓缩。LISi 的一个相关应用是在检测阿扑吗啡（APO）中的发现，APO 是一种用于治疗帕金森病的药物。与使用金 SERS 衬底获得的结果相比，LISi 允许在没有氧化迹象的情况下检测 APO。这为在未来的 APO 个性化输送系统中使用 Si/SiOx SERS 检测技术提供了可能。
