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超高效液相色谱-质谱联用引导下从……中分离单醚键二聚体2-(2-苯乙基)色酮

UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from .

作者信息

Kuang Tongdong, Chen Hui-Qin, Wang Hao, Kong Fan-Dong, Cai Cai-Hong, Dong Wen-Hua, Yuan Jing-Zhe, Mei Wen-Li, Dai Hao-Fu

机构信息

Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences Haikou 571101 PR China

Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences Haikou 571101 PR China.

出版信息

RSC Adv. 2019 May 31;9(30):17025-17034. doi: 10.1039/c9ra02597a. eCollection 2019 May 29.

DOI:10.1039/c9ra02597a
PMID:35519867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9064565/
Abstract

Eleven novel uncommon single ether linkage dimeric 2-(2-phenylethyl)chromones (aquilasinenones A-K) were isolated by a UPLC-MS guided method from artificial hole-induced agarwood originating from . Their structures were unambiguously deduced using HRESIMS data, detailed 1D and 2D NMR spectroscopic analysis, and experimental ECD spectra. All the compounds were tested for acetylcholinesterase (AChE) inhibitory activity by Ellman's colorimetric method, and compounds 9-11 displayed weak AChE inhibitory activity with the inhibition ranging from 15.6% to 16.8% at a concentration of 50 μg mL.

摘要

采用超高效液相色谱-质谱联用（UPLC-MS）引导的方法，从人工打洞诱导产生的沉香中分离得到了11种新型罕见的单醚键二聚体2-(2-苯乙基)色酮（鹰木素A-K）。通过高分辨电喷雾电离质谱（HRESIMS）数据、详细的一维和二维核磁共振光谱分析以及实验电子圆二色光谱（ECD）明确推导了它们的结构。采用Ellman比色法对所有化合物进行了乙酰胆碱酯酶（AChE）抑制活性测试，化合物9-11表现出较弱的AChE抑制活性，在浓度为50 μg/mL时，抑制率为15.6%至16.8%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9064565/86e0c01ee633/c9ra02597a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9064565/d94e6c657fdb/c9ra02597a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9064565/9235fc8d3d8d/c9ra02597a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9064565/ee474a6ade66/c9ra02597a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9064565/86e0c01ee633/c9ra02597a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9064565/d94e6c657fdb/c9ra02597a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9064565/9235fc8d3d8d/c9ra02597a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9064565/ee474a6ade66/c9ra02597a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec7f/9064565/86e0c01ee633/c9ra02597a-f4.jpg

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本文引用的文献

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Overview of sesquiterpenes and chromones of agarwood originating from four main species of the genus .沉香中倍半萜类化合物和色酮类化合物的概述，沉香来源于该属四个主要物种。
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