Soto-Rey I, Rehr M, Bruland P, Zeidler C, Riepe C, Steinke S, Ständer S, Dugas M, Storck M
Institute of Medical Informatics, University of Münster, Münster, Germany.
Center for Chronic Pruritus and Department of Dermatology, University Hospital Münster, University of Münster, Münster, Germany.
Methods Inf Med. 2018 Dec;57(S 02):e107-e114. doi: 10.1055/s-0038-1675397. Epub 2018 Nov 19.
Patient-reported outcomes (PROs) are information provided directly by patients that helps in improving patient diagnosis and treatment. Validated translations of PROs can be used to treat international patients. Electronic systems and especially mobile devices provide a great opportunity for their collection; however, these systems are normally study-oriented and therefore single language, not scalable, and not interoperable.
This article reports the development of a multicenter, multilingual, and interoperable electronic PRO (ePRO) system and evaluates its user satisfaction in an international clinical study.
The ePRO named "MoPat2" was developed using Java 8 and jQuery Mobile 1.4.5. The system was evaluated in the context of the European dermatology project "European Network on Assessment of Severity and Burden of Pruritus"(PruNet), which aimed to unify the assessment of itch in routine dermatological care in Europe. Twenty-six clinicians and 468 patients from 8 European clinical centers were asked to complete a user satisfaction questionnaire regarding the use of MoPat2 with a tablet personal computer. The results were then analyzed and correlated with the age, gender, and language of the respondents.
MoPat2 was enhanced with multilingual capabilities and is now able to conduct surveys in several languages, as well as store and display the results in the local language. The interviewed clinicians rated the system with an average score of 2.0 ("good") in a 1 to 5 Likert scale. Note that 93.9% of the patients (439 of 468) reported having got on well using the system and 88.9% (416 of 456) would be willing to further use it. The age of the patients not willing to further use MoPat2 was, in average, considerably higher than the age of patients willing to use the system.
This study represents the first use of an ePRO system for the collection of multilingual PROs in an international, multicenter setting. MoPat2 has been evaluated by both clinicians and patients in the context of a European dermatological study, resulting in a high user satisfaction. The system will be further developed to include new features such as patient follow-ups outside of the clinical setting.
患者报告结局（PROs）是患者直接提供的信息，有助于改善患者的诊断和治疗。经过验证的PROs翻译可用于治疗国际患者。电子系统，尤其是移动设备为收集这些信息提供了绝佳机会；然而，这些系统通常以研究为导向，因此是单一语言的，不可扩展且不可互操作。
本文报告了一个多中心、多语言且可互操作的电子PRO（ePRO）系统的开发，并在一项国际临床研究中评估了其用户满意度。
名为“MoPat2”的ePRO系统使用Java 8和jQuery Mobile 1.4.5开发。该系统在欧洲皮肤病学项目“欧洲瘙痒严重程度和负担评估网络”（PruNet）的背景下进行了评估，该项目旨在统一欧洲常规皮肤病护理中瘙痒的评估。来自8个欧洲临床中心的26名临床医生和468名患者被要求使用平板电脑完成一份关于使用MoPat2的用户满意度问卷。然后对结果进行分析，并与受访者的年龄、性别和语言进行关联。
MoPat2增强了多语言功能，现在能够用多种语言进行调查，并以当地语言存储和显示结果。接受采访的临床医生在1至5李克特量表中对该系统的平均评分为2.0（“良好”）。请注意，93.9%的患者（468名中的439名）报告使用该系统情况良好，88.9%（456名中的416名）愿意进一步使用它。不愿意进一步使用MoPat2的患者平均年龄明显高于愿意使用该系统的患者。
本研究首次在国际多中心环境中使用ePRO系统收集多语言PROs。MoPat2已在一项欧洲皮肤病学研究中由临床医生和患者进行了评估，获得了较高的用户满意度。该系统将进一步开发，以纳入诸如临床环境之外的患者随访等新功能。
