Li M M, Guo L Q, Li S S, Zhang Q, Zhao D D, Zhang B Y, Dang S N, Yan H
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Oct 10;39(10):1333-1338. doi: 10.3760/cma.j.issn.0254-6450.2018.10.009.
To analyze the relationship between medication taken during pregnancy and congenital heart disease of the newborns. A large cross-sectional survey was conducted between August and November 2013. A questionnaire survey was conducted among the childbearing aged women, selected through multistage stratified random sampling in Shaanxi from 2010 to 2013. All of the childbearing aged women under study were in pregnancy and with definite pregnancy outcomes. Multivariable Poisson regression was conducted for data analyses. A total of 28 680 cases were included in this study. The proportion of medication taken at any time during pregnancy was 16.0%, and the prevalence of congenital heart disease among the newborns was 67.9/10 000. After adjustment for factors as general demographic characteristic, history of heart disease and drug allergy and the situation of disease during pregnancy of these women, results from the multivariable Poisson regression showed that, factors as taking drugs (=1.95, 95: 1.42- 2.68), cold medicine (=1.68, 95: 1.07-2.64), antibiotics (=1.90, 95: 1.25-2.90), salicylates (=5.01, 95: 1.84-13.64) and antifungal drugs (=10.22, 95: 3.25-32.19) during pregnancy were all related to congenital heart disease, and with the history of taking cold medicine (=1.90, 95: 1.01-3.61), antibiotics (=2.18, 95: 1.17-4.06), salicylates (=6.07, 95: 1.45-25.41), antifungal drugs (=21.01, 95: 4.17-105.87) and other drugs (=2.31, 95: 1.19-4.47) during early pregnancy. These factors were with higher risks for congenital heart disease. Women of childbearing age who took cold medicine, antibiotics, salicylic acid drugs, antifungal drugs and other drugs during early pregnancy would increase the risks related to congenital heart diseases.
分析孕期用药与新生儿先天性心脏病之间的关系。2013年8月至11月进行了一项大型横断面调查。对2010年至2013年在陕西通过多阶段分层随机抽样选取的育龄妇女进行问卷调查。所有纳入研究的育龄妇女均处于孕期且有明确的妊娠结局。采用多变量泊松回归进行数据分析。本研究共纳入28680例病例。孕期任何时间用药的比例为16.0%，新生儿先天性心脏病的患病率为67.9/10000。在对这些妇女的一般人口学特征、心脏病史、药物过敏史以及孕期疾病情况等因素进行调整后，多变量泊松回归结果显示，孕期服用药物（=1.95，95%置信区间：1.42 - 2.68）、感冒药（=1.68，95%置信区间：1.07 - 2.64）、抗生素（=1.90，95%置信区间：1.25 - 2.90）、水杨酸盐（=5.01，95%置信区间：1.84 - 13.64）和抗真菌药（=10.22，95%置信区间：3.25 - 32.19）均与先天性心脏病有关，且孕早期服用感冒药（=1.90，95%置信区间：1.01 - 3.61）、抗生素（=2.18，95%置信区间：1.17 - 4.06）、水杨酸盐（=6.07，95%置信区间：1.45 - 25.41）、抗真菌药（=21.01，95%置信区间：4.17 - 105.87）和其他药物（=2.31，95%置信区间：1.19 - 4.47）这些因素与先天性心脏病的风险更高。孕早期服用感冒药、抗生素、水杨酸类药物、抗真菌药和其他药物的育龄妇女会增加患先天性心脏病的相关风险。
