Jones Daniel P, Patel Jyoti
Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK.
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, British Heart Foundation Centre of Research Excellence, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Biology (Basel). 2018 Nov 16;7(4):49. doi: 10.3390/biology7040049.
Cardiovascular disease is a leading cause of morbidity and mortality in the Western world and represents an enormous global health burden. Significant advances have been made in the conservative, medical and surgical management across the range of cardiovascular diseases however the inflammatory components of these diseases have traditionally been neglected. Inflammation is certainly a key component of atherosclerosis, a chronic inflammatory condition, but it is at least correlative and predictive of risk in many other aspects of cardiovascular medicine ranging from heart failure to outcomes following reperfusion strategies. Inflammation therefore represents significant potential for future risk stratification of patients as well as offering new therapeutic targets across cardiovascular medicine. This review explores the role of inflammation in several of the major aspects of cardiovascular medicine focusing on current and possible future examples of the targeting of inflammation in prognosis and therapy. It concludes that future directions of cardiovascular research and clinical practice should seek to identify cohorts of patients with a significant inflammatory component to their cardiovascular condition or reaction to cardiovascular intervention. These patients might benefit from therapeutic strategies mounted against the inflammatory components implicated in their condition.
心血管疾病是西方世界发病和死亡的主要原因，也是全球巨大的健康负担。在心血管疾病的保守治疗、药物治疗和手术治疗方面已取得重大进展，然而这些疾病的炎症成分传统上一直被忽视。炎症无疑是动脉粥样硬化（一种慢性炎症性疾病）的关键组成部分，但在心血管医学的许多其他方面，从心力衰竭到再灌注策略后的结果，炎症至少与风险相关且具有预测性。因此，炎症在未来患者风险分层方面具有巨大潜力，同时也为心血管医学提供了新的治疗靶点。本综述探讨了炎症在心血管医学几个主要方面的作用，重点关注当前以及未来可能针对炎症进行预后和治疗的实例。结论是，心血管研究和临床实践的未来方向应寻求识别那些心血管疾病状况或对心血管干预反应中存在显著炎症成分的患者群体。这些患者可能会从针对其病情中所涉及的炎症成分的治疗策略中受益。
