Grup de Nutrició Comunitària i Estrès Oxidatiu, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, 07122 Palma, Spain.
CIBER: CB12/03/30038 Fisiopatología de la Obesidad la Nutrición, CIBEROBN, Instituto de Salud Carlos III (ISCIII), University of Balearic Islands, 07122 Palma, Spain.
Nutrients. 2018 Nov 16;10(11):1780. doi: 10.3390/nu10111780.
A chronic inflammatory state is a major characteristic of the aging process, and physical activity is proposed as a key component for healthy aging. Our aim was to evaluate the body composition, hypertension, lipid profile, and inflammatory status of older adults, and these factors' association with physical activity. A total of 116 elderly volunteers were categorized into terciles of quantitative metabolic equivalents of task (MET). Subjects in the first and third terciles were defined as sedentary and active subjects, respectively. Anthropometric and biochemical parameters, hemograms, and inflammatory markers were measured in plasma or peripheral mononuclear blood cells (PBMCs). The active groups exercised more than their sedentary counterparts. The practice of physical activity was accompanied by lower weight, fat mass, body mass index, and diastolic blood pressure when compared to a more sedentary life-style. Physical activity also lowered the haematocrit and total leukocyte, neutrophil, and lymphocyte counts. The practice of exercise induced a decrease in the IL-6 circulating levels and the TLR2 protein levels in PBMCs, while the expression of the anti-inflammatory IL-10 was activated in active subjects. The regular practice of physical activity exerts beneficial effects on body composition and the anti-inflammatory status of old people.
慢性炎症状态是衰老过程的一个主要特征，而身体活动被认为是健康衰老的关键组成部分。我们的目的是评估老年人的身体成分、高血压、血脂谱和炎症状态，以及这些因素与身体活动的关联。共有 116 名老年志愿者被分为定量代谢当量任务（MET）的三分位数。第一和第三三分位数的受试者分别被定义为久坐和活跃的受试者。测量了人体测量学和生化参数、血液常规和炎症标志物在血浆或外周血单核细胞（PBMC）中。与更久坐的生活方式相比，积极组的运动量更大。与更久坐的生活方式相比，身体活动还降低了体重、脂肪量、体重指数和舒张压。身体活动还降低了循环 IL-6 水平和 PBMC 中 TLR2 蛋白水平，而在积极组中，抗炎性 IL-10 的表达被激活。定期进行身体活动对老年人的身体成分和抗炎状态有有益的影响。
