Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Viale del Policlinico 155, 00161, Rome, Italy.
Laboratory of Virology, Department of Molecular Medicine, University of Rome Sapienza, Rome, Italy.
AIDS Behav. 2020 Apr;24(4):1042-1050. doi: 10.1007/s10461-019-02510-y.
Several studies evidenced that a sedentary lifestyle is related with higher levels of systemic inflammation and highlighted that physical activity can trigger anti-inflammatory effects. To evaluate the impact of self-prescribed physical activity on fitness status, metabolism, inflammation and immune-activation in people living with HIV, an interim analysis of the results of the clinical trial PRIMO (NCT03392805) was performed. Patients enrolled were divided in 2 groups on the basis of self-prescribed physical activity: a physically active group (self-prescribed physical activity) and a sedentary group. Physical fitness was evaluated by sport medicine specialists and related to nutritional status, anthropometric variables, adipokines levels (adiponectin, leptin, resistin), peripheral immune-activation (CD38, HLA-DR on CD4 and CD8), and plasma inflammatory markers (IL-6 and TNF-α). The physically active group had a better profile in anthropometric measures and aerobic fitness but did not show lower levels of immune-activation compared to sedentary group. Also serum IL-6, TNF-α, and adipokines levels showed no statistical differences. On the basis of these data, a regular self-organized physical activity seems useful to improve cardio-respiratory fitness, but unable to control HIV-related immune-activation.
多项研究表明，久坐的生活方式与更高水平的全身炎症有关，并强调体力活动可以引发抗炎作用。为了评估自行规定的体育活动对艾滋病毒感染者的健康状况、新陈代谢、炎症和免疫激活的影响，对临床试验 PRIMO（NCT03392805）的结果进行了中期分析。根据自行规定的体育活动，将纳入的患者分为两组：活跃组（自行规定的体育活动）和久坐组。运动医学专家评估了身体适应性，并将其与营养状况、人体测量变量、脂肪因子水平（脂联素、瘦素、抵抗素）、外周免疫激活（CD38、CD4 和 CD8 上的 HLA-DR）和血浆炎症标志物（IL-6 和 TNF-α）相关联。活跃组在人体测量指标和有氧适能方面表现更好，但与久坐组相比，免疫激活水平没有更低。此外，血清 IL-6、TNF-α 和脂肪因子水平没有统计学差异。基于这些数据，定期的自我组织的体育活动似乎有助于提高心肺适能，但无法控制与 HIV 相关的免疫激活。
