Cavalcante Paula Andréa Malveira, Gregnani Marcos Fernandes, Henrique Jessica Salles, Ornellas Fábio Henrique, Araújo Ronaldo Carvalho
Medicine (Nephrology) Program, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.
Laboratory of Exercise Genetics and Metabolism, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.
Sports Med Open. 2017 Nov 28;3(1):42. doi: 10.1186/s40798-017-0111-2.
Only a few studies have addressed the relationship between toll-like receptors 2 and 4 (TLR2 and TLR4) and the production of local and systemic cytokines in response to physical exercise, and they have produced conflicting results. We aimed to determine whether acute and chronic exercise outcomes are associated with changes in TLR2 and TLR4 expression and signaling and if so, the mechanisms that connect them.
PubMed database were consulted. This systematic review selected 39 articles, 26 involving humans and 13 based on rodents.
In acute resistance exercise studies, 75% reported a decrease in TLR4 or TLR2 expression and 25% did not find differences. For chronic resistance exercise studies, 67% reported a reduction of expression and 33% did not find differences. Studies of both types reported reductions in pro-inflammatory cytokines. In acute aerobic exercise studies, 40% revealed a decline in the expression of the receptors, 7% reported no significant difference, 40% showed an increase, and 13% did not evaluate their expression. Fifty-eight percent of studies of chronic aerobic exercise revealed a reduction in expression, 17% did not find a difference, and 25% reported increases; they also suggested that the expression of the receptors might be correlated with that of inflammatory cytokines. In studies on combined exercise, 50% reported a decline in receptors expression and 50% did not find a difference.
The majority of the articles (54%) link different types of exercise to a decline in TLR4 and TLR2 expression. However, aerobic exercise may induce inflammations through its influence on these receptor pathways. Higher levels of inflammation were seen in acute sessions (40%) than regular sessions (25%).
仅有少数研究探讨了Toll样受体2和4（TLR2和TLR4）与体育锻炼后局部和全身细胞因子产生之间的关系，且结果相互矛盾。我们旨在确定急性和慢性运动结果是否与TLR2和TLR4表达及信号传导的变化相关，若相关，找出其中的联系机制。
查阅了PubMed数据库。该系统评价选取了39篇文章，其中26篇涉及人类研究，13篇基于啮齿动物研究。
在急性抗阻运动研究中，75%的研究报告TLR4或TLR2表达下降，25%未发现差异。对于慢性抗阻运动研究，67%报告表达降低，33%未发现差异。两类研究均报告促炎细胞因子减少。在急性有氧运动研究中，40%显示受体表达下降，7%报告无显著差异，40%显示增加，13%未评估其表达。58%的慢性有氧运动研究显示表达降低，17%未发现差异，25%报告增加；这些研究还表明受体表达可能与炎性细胞因子表达相关。在综合运动研究中，50%报告受体表达下降，50%未发现差异。
大多数文章（54%）将不同类型的运动与TLR4和TLR2表达下降联系起来。然而，有氧运动可能通过影响这些受体途径诱导炎症。急性运动时出现较高水平炎症的比例（40%）高于常规运动时（25%）。
