School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1010, New Zealand.
Department of Neurobiology, Tel-Aviv University, Ramat-Aviv 69978, Israel.
Mar Drugs. 2018 Nov 18;16(11):454. doi: 10.3390/md16110454.
Fucoidan, a sulfated polysaccharide extracted from brown seaweeds, has been shown to possess various antioxidant, anticoagulant, antiviral, and anticancer functions. In this study, we focused on low molecular weight fucoidan (LMWF) which was extracted from New Zealand , and investigated its anti-proliferative effects, combined with a quadruplex-forming oligonucleotide aptamer (GroA, AS1411), a powerful cell surface Nucleolin inhibitor, in prostate cancer cells. We examined LMWF (<10 kDa) and compared it with laboratory grade Fucoidan purchased from Sigma (FS), all extracted from the same seaweed species . We found that LMWF significantly improved the anti-proliferative effect of GroA, as it decreased cancer cell growth and viability and increased cell death. This research may provide the foundation for LMWF to be used against prostate cancers as a supplement therapy in combination with other therapeutic agents.
褐藻糖胶是一种从褐藻中提取的硫酸多糖，已被证明具有多种抗氧化、抗凝、抗病毒和抗癌功能。在这项研究中，我们专注于从新西兰提取的低分子量褐藻糖胶（LMWF），并研究了其与四链体形成寡核苷酸适体（GroA，AS1411）联合使用时对前列腺癌细胞的抗增殖作用，GroA 是一种强大的细胞表面核仁素抑制剂。我们检测了 LMWF（<10 kDa），并将其与从同一海藻物种中提取的西格玛实验室级褐藻糖胶（FS）进行了比较。我们发现 LMWF 显著增强了 GroA 的抗增殖作用，因为它降低了癌细胞的生长和活力，增加了细胞死亡。这项研究可能为 LMWF 作为补充治疗与其他治疗剂联合用于治疗前列腺癌提供了基础。
