Sun Yi-Fan, Zhang Xia, Wang Xiao-Yan, Jia Wei
Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Zhongguo Zhong Yao Za Zhi. 2018 Oct;43(19):3927-3932. doi: 10.19540/j.cnki.cjcmm.20180604.001.
As a traditional Chinese medicine in China, ginseng has a wide range of medicinal and health value. At present, the nutritional value of ginseng as a medicinal food has been a hotspot in studies. Intestinal flora plays an important role in the organism, which has been confirmed by many researchers. In order to find out the effect of long-term intake of ginseng extracts on the gut microbiota structure of rats, MiSeq sequencing platform was applied in macro gene sequencing of cecal contents in the long-term use of ginseng extracts modelin rats. According to the findings, after long-term administration with ginseng extracts, probiotics such as Bifidobacterium, Lactobacillus, Allobaculum and Clostridium, in the intestinal flora of rats were significantly increased, suggesting that long-term intake of ginseng extracts could facilitate the growth of probiotics. Meanwhile, some pathogenic bacteria, such as Butyricimonas, Parabacteroides, Alistipes, Helicobacter, were significantly down-regulated, indicating that long-term intake of ginseng extracts may have a positive effect in inhibiting the colonization of pathogenic bacteria. In conclusion, this study provided an important basis for the research on the effect of long-term use of ginseng extracts on the intestinal flora of rats.
人参作为中国的一种传统中药，具有广泛的药用和保健价值。目前，人参作为药食两用的营养价值已成为研究热点。肠道菌群在机体中发挥着重要作用，这已得到许多研究者的证实。为了探究长期摄入人参提取物对大鼠肠道微生物群结构的影响，在长期使用人参提取物的大鼠模型中，应用MiSeq测序平台对盲肠内容物进行宏基因测序。研究结果表明，长期给予大鼠人参提取物后，大鼠肠道菌群中的双歧杆菌、乳酸杆菌、别氏菌和梭菌等益生菌显著增加，这表明长期摄入人参提取物可促进益生菌生长。同时，丁酸单胞菌、副拟杆菌、艾氏杆菌、幽门螺杆菌等一些病原菌显著下调，这表明长期摄入人参提取物可能对抑制病原菌定植具有积极作用。总之，本研究为长期使用人参提取物对大鼠肠道菌群影响的研究提供了重要依据。
