来自于……的异喹啉生物碱

Isoquinoline alkaloids from .

作者信息

Majrashi Taghreed A, Zulfiqar Fazila, Chittiboyina Amar G, Ali Zulfiqar, Khan Ikhlas A

机构信息

a National Center for Natural Products Research, School of Pharmacy, University of Mississippi University , MS , USA.

b Department of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi University , MS , USA.

出版信息

Nat Prod Res. 2019 Oct;33(19):2823-2829. doi: 10.1080/14786419.2018.1504045. Epub 2018 Nov 20.

DOI:10.1080/14786419.2018.1504045

PMID:30453785

Abstract

A new aporphine glycoside, (-)anolobine-9-D-glucopyranoside was isolated from the twigs of pawpaw () along with 7 known alkaloids including five aporphine alkaloids (anolobine, nornuciferine, norushinsunine, liriodenine, and lysicamine), a proaporhine alkaloid (stepharine), and a tetrahydrobenzylisoquinoline alkaloid (coclaurine). Among these compounds, nornuciferine, lysicamine, stepharine, and coclaurine are reported for the first time from this plant. The structure of the new compound was elucidated by spectroscopic methods, including 1 D, 2 D NMR, and HRESI-MS. The absolute configuration of compounds , , and was determined by CD experiment.

摘要

从番木瓜（）的嫩枝中分离出一种新的阿朴啡糖苷，即（-）阿诺洛宾-9-D-吡喃葡萄糖苷，同时还分离出7种已知生物碱，包括5种阿朴啡生物碱（阿诺洛宾、去甲荷叶碱、去甲乌药碱、鹅掌楸碱和丽西卡明）、1种原阿朴啡生物碱（千金藤碱）和1种四氢苄基异喹啉生物碱（劳丹宁）。在这些化合物中，去甲荷叶碱、丽西卡明、千金藤碱和劳丹宁首次从该植物中报道。通过光谱方法，包括一维、二维核磁共振和高分辨电喷雾电离质谱，阐明了新化合物的结构。通过圆二色光谱实验确定了化合物、、和的绝对构型。