Matsushige Ayano, Kotake Yaichiro, Matsunami Katsuyoshi, Otsuka Hideaki, Ohta Shigeru, Takeda Yoshio
Department of Xenobiotic Metabolism and Molecular Toxicology, Graduate School of Biomedical Sciences, Hiroshima University.
Chem Pharm Bull (Tokyo). 2012;60(2):257-9. doi: 10.1248/cpb.60.257.
Atypical Parkinsonism in the Caribbean Island Guadeloupe is thought to be associated with the consumption of plants of the Annonaceae family, especially Annona muricata (soursop). In this study, a new aporphine alkaloid named annonamine (1) was isolated from the leaves of A. muricata L. together with four known benzylisoquinoline alkaloids (2-5). The structures of the isolated compounds were elucidated by the spectroscopic method.
加勒比海岛瓜德罗普岛的非典型帕金森病被认为与番荔枝科植物的食用有关，尤其是刺果番荔枝（番荔枝）。在本研究中，从刺果番荔枝的叶子中分离出一种名为番荔枝胺（1）的新阿朴啡生物碱以及四种已知的苄基异喹啉生物碱（2-5）。通过光谱法阐明了分离出的化合物的结构。
