Department of Pediatrics, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, South Korea.
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Lipids Health Dis. 2018 Nov 20;17(1):260. doi: 10.1186/s12944-018-0902-6.
Ultraviolet-B (UVB) light exposure is the major risk factor for developing a pterygium, and serum 25-hydroxyvitamin D (25(OH)D) level is an objective measure of UVB light exposure. In this study, we investigated the association between pterygium, sun exposure, and serum 25(OH)D.
This population-based, cross-sectional study comprised 12,258 adults (aged ≥19 years) participating in the fifth annual Korea National Health and Nutrition Examination Survey from 2010 to 2012. The enrolled subjects underwent interviews, clinical examinations, and laboratory investigations. The serum 25(OH)D levels were measured, and pterygium was examined by using a slit lamp. We used three adjusted logistic regression models and selected covariates as potential confounders.
The overall prevalence of pterygium was 7.09, and 53.1% of these subjects were women. The prevalence of pterygium was higher in elderly subjects and those who lived at low latitudes. In multivariate analysis with adjustment for confounding factors, subjects with a serum 25(OH)D level > 30 ng/mL, 25-30 ng/mL, and 15-20 ng/mL had an odds ratio (OR) (95% confidence interval [CI]) of 1.565 (1.035-2.366), 1.545 (1.086-2.198), 1.8 (1.358-2.386), and 1.535 (1.216-1.938), respectively, compared to those with a serum 25(OH)D level < 15 ng/mL. Subjects with a daily sun exposure > 5 h had an OR (95% CI) of 1.761 (1.395-2.223) compared to subjects with a daily sun exposure < 2 h.
The present study provides epidemiological evidence of an association of daily sun exposure and serum 25(OH)D levels with pterygium in a representative Korean population.
紫外线-B（UVB）照射是翼状胬肉形成的主要危险因素，血清 25-羟维生素 D（25（OH）D）水平是紫外线-B 照射的客观衡量标准。本研究调查了翼状胬肉、阳光暴露和血清 25（OH）D 之间的关系。
本研究采用基于人群的横断面研究设计，纳入了 2010 年至 2012 年参加第五次韩国国家健康和营养检查调查的 12258 名年龄≥19 岁的成年人。纳入的受试者接受了访谈、临床检查和实验室检查。检测血清 25（OH）D 水平，并使用裂隙灯检查翼状胬肉。我们使用了三个调整后的逻辑回归模型，并选择了潜在的混杂因素作为协变量。
翼状胬肉的总体患病率为 7.09%，其中 53.1%为女性。在多变量分析中，调整了混杂因素后，血清 25（OH）D 水平>30ng/mL、25-30ng/mL 和 15-20ng/mL 的受试者患翼状胬肉的比值比（OR）（95%置信区间[CI]）分别为 1.565（1.035-2.366）、1.545（1.086-2.198）、1.8（1.358-2.386）和 1.535（1.216-1.938），与血清 25（OH）D 水平<15ng/mL 的受试者相比。与每日阳光暴露<2 小时的受试者相比，每日阳光暴露>5 小时的受试者患翼状胬肉的 OR（95%CI）为 1.761（1.395-2.223）。
本研究提供了流行病学证据，表明在韩国代表性人群中，每日阳光暴露和血清 25（OH）D 水平与翼状胬肉有关。
