Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Republic of Singapore.
Ophthalmology. 2012 Aug;119(8):1509-15. doi: 10.1016/j.ophtha.2012.02.009. Epub 2012 Apr 10.
To describe the prevalence and risk factors of pterygium in a multiethnic Asian population and to examine racial differences.
Population-based study in Singapore, located 1° north of the equator.
Data were analyzed from 8906 participants from 3 population-based studies of Malays, Indians, and Chinese persons 40 years of age and older conducted between 2004 and 2011.
Standardized slit-lamp examinations were performed by trained study ophthalmologists to examine the anterior segment for evidence of pterygium. Every subject underwent standardized systemic and ocular examinations, interviewer-administered questionnaires, and blood investigations for risk factor assessment. Regression and principle component analysis models were constructed to study the relationship of race and other factors to pterygium.
Any pterygium and severe (grade 3 or opaque) pterygium.
The overall prevalence of any pterygium was 10.1% (n = 900), of which severe pterygium was seen in 1.6% (n = 142). The prevalence of any pterygium was more common in Malays (15.5%) than Chinese (7.0%; P<0.001) or Indians (7.0%; P<0.001). Multivariate analysis revealed increasing age (P<0.001), male gender (P<0.001), Malay race (P<0.001), and having a poorer education level (P<0.001) as significant factors for any pterygium. Race contributed significantly to presence of any pterygium (41%; P<0.001) or presence in both eyes (33%; P<0.001) compared with other risk factors. Severe pterygium was associated with outdoor occupation (P = 0.02), but race was not a significant risk factor in multivariate analysis.
This population-based study in Asian persons of different races living in the same geographical location at the equator indicated that race is a significant risk factor for pterygium, with Malays having higher prevalence than Indians and Chinese, while controlling for other risk factors.
描述多民族亚洲人群中翼状胬肉的患病率和危险因素，并探讨种族差异。
在赤道以北的新加坡进行的基于人群的研究。
数据分析来自 2004 年至 2011 年间进行的三项基于人群的马来人、印度人和华人 40 岁及以上人群研究中的 8906 名参与者。
由经过培训的研究眼科医生进行标准化的裂隙灯检查，以检查前节是否有翼状胬肉。每位受试者均接受标准化的全身和眼部检查、访谈者进行的问卷调查以及血液检查以评估危险因素。构建回归和主成分分析模型，以研究种族和其他因素与翼状胬肉的关系。
任何翼状胬肉和严重（3 级或不透明）翼状胬肉。
任何翼状胬肉的总体患病率为 10.1%（n=900），其中严重翼状胬肉的患病率为 1.6%（n=142）。马来人（15.5%）的任何翼状胬肉患病率高于华人（7.0%；P<0.001）或印度人（7.0%；P<0.001）。多变量分析显示，年龄增长（P<0.001）、男性（P<0.001）、马来人种族（P<0.001）和较低的教育水平（P<0.001）是任何翼状胬肉的重要因素。种族对任何翼状胬肉的存在（41%；P<0.001）或双眼存在（33%；P<0.001）的贡献显著高于其他危险因素。严重翼状胬肉与户外职业有关（P=0.02），但在多变量分析中种族不是一个显著的危险因素。
本项在赤道同一地理位置的不同种族亚洲人群中进行的基于人群的研究表明，种族是翼状胬肉的一个重要危险因素，马来人比印度人和华人的患病率更高，而其他危险因素则得到控制。
