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抑制细胞因子信号转导（SOCS）基因在乳腺癌中下调。

Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer.

机构信息

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, P.O.Box: 19857-17443, Tehran, Iran.

Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

World J Surg Oncol. 2018 Nov 19;16(1):226. doi: 10.1186/s12957-018-1529-9.

DOI:10.1186/s12957-018-1529-9
PMID:30453988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6245766/
Abstract

BACKGROUND

The suppressor of cytokine signaling (SOCS) family of proteins are inhibitors of the cytokine-activated Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. We aimed at evaluation of expression of SOCS genes in breast cancer.

METHODS

We evaluated expression of SOCS1-3 and SOCS5 genes in breast cancer samples compared with the corresponding adjacent non-cancerous tissues (ANCTs).

RESULTS

All assessed SOCS genes were significantly downregulated in tumoral tissues compared with ANCTs. SOCS1 and SOCS2 genes were significantly overexpressed in higher grade samples, but SOCS3 had the opposite trend. Significant correlations were found between expression levels of SOCS genes. The SOCS1 and SOCS2 expression levels had the best specificity and sensitivity values respectively for breast cancer diagnosis.

CONCLUSION

The current study provides further evidence for contribution of SOCS genes in breast cancer.

摘要

背景

细胞因子信号转导抑制因子（SOCS）家族蛋白是细胞因子激活的 Janus 激酶/转录信号转导激活因子（JAK/STAT）信号通路的抑制剂。我们旨在评估 SOCS 基因在乳腺癌中的表达。

方法

我们评估了 SOCS1-3 和 SOCS5 基因在乳腺癌样本与相应的相邻非癌组织（ANCT）中的表达。

结果

与 ANCT 相比，所有评估的 SOCS 基因在肿瘤组织中均显著下调。SOCS1 和 SOCS2 基因在较高分级的样本中显著过表达，但 SOCS3 则相反。SOCS 基因的表达水平之间存在显著相关性。SOCS1 和 SOCS2 的表达水平分别对乳腺癌诊断具有最佳的特异性和敏感性。

结论

本研究为 SOCS 基因在乳腺癌中的作用提供了进一步的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19b/6245766/067d4e4efc01/12957_2018_1529_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19b/6245766/291eda7e46ee/12957_2018_1529_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19b/6245766/067d4e4efc01/12957_2018_1529_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19b/6245766/291eda7e46ee/12957_2018_1529_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19b/6245766/067d4e4efc01/12957_2018_1529_Fig2_HTML.jpg

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Front Immunol. 2017 Feb 8;8:70. doi: 10.3389/fimmu.2017.00070. eCollection 2017.
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Expression of SOCS1 and CXCL12 Proteins in Primary Breast Cancer Are Associated with Presence of Circulating Tumor Cells in Peripheral Blood.原发性乳腺癌中SOCS1和CXCL12蛋白的表达与外周血循环肿瘤细胞的存在相关。
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Suppressor of cytokine signaling (SOCS) genes are silenced by DNA hypermethylation and histone deacetylation and regulate response to radiotherapy in cervical cancer cells.
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Triple-negative Breast Cancer: Identification of circRNAs With Efficacy in Preclinical Models.三阴性乳腺癌：具有临床前模型疗效的 circRNAs 的鉴定。
Cancer Genomics Proteomics. 2023 Mar-Apr;20(2):117-131. doi: 10.21873/cgp.20368.
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A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer.一种用于预测花生四烯乙醇胺对结直肠癌影响的斑马鱼HCT116异种移植模型。
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