抑制细胞因子信号转导（SOCS）基因在乳腺癌中下调。
Suppressor of cytokine signaling (SOCS) genes are downregulated in breast cancer.
机构信息
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, P.O.Box: 19857-17443, Tehran, Iran.
Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
World J Surg Oncol. 2018 Nov 19;16(1):226. doi: 10.1186/s12957-018-1529-9.
BACKGROUND
The suppressor of cytokine signaling (SOCS) family of proteins are inhibitors of the cytokine-activated Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway. We aimed at evaluation of expression of SOCS genes in breast cancer.
METHODS
We evaluated expression of SOCS1-3 and SOCS5 genes in breast cancer samples compared with the corresponding adjacent non-cancerous tissues (ANCTs).
RESULTS
All assessed SOCS genes were significantly downregulated in tumoral tissues compared with ANCTs. SOCS1 and SOCS2 genes were significantly overexpressed in higher grade samples, but SOCS3 had the opposite trend. Significant correlations were found between expression levels of SOCS genes. The SOCS1 and SOCS2 expression levels had the best specificity and sensitivity values respectively for breast cancer diagnosis.
CONCLUSION
The current study provides further evidence for contribution of SOCS genes in breast cancer.
背景
细胞因子信号转导抑制因子（SOCS）家族蛋白是细胞因子激活的 Janus 激酶/转录信号转导激活因子（JAK/STAT）信号通路的抑制剂。我们旨在评估 SOCS 基因在乳腺癌中的表达。
方法
我们评估了 SOCS1-3 和 SOCS5 基因在乳腺癌样本与相应的相邻非癌组织（ANCT）中的表达。
结果
与 ANCT 相比，所有评估的 SOCS 基因在肿瘤组织中均显著下调。SOCS1 和 SOCS2 基因在较高分级的样本中显著过表达，但 SOCS3 则相反。SOCS 基因的表达水平之间存在显著相关性。SOCS1 和 SOCS2 的表达水平分别对乳腺癌诊断具有最佳的特异性和敏感性。
结论
本研究为 SOCS 基因在乳腺癌中的作用提供了进一步的证据。
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