儿童肾移植的长期预后
Long-Term Outcomes of Kidney Transplantation in Children.
作者信息
Winterberg Pamela D, Garro Rouba
机构信息
Division of Pediatric Nephrology, Emory University School of Medicine, Children's Pediatric Institute, 2015 Uppergate Drive NE, 5th Floor, Atlanta, GA 30322, USA.
Division of Pediatric Nephrology, Emory University School of Medicine, Children's Pediatric Institute, 2015 Uppergate Drive NE, 5th Floor, Atlanta, GA 30322, USA.
出版信息
Pediatr Clin North Am. 2019 Feb;66(1):269-280. doi: 10.1016/j.pcl.2018.09.008.
Abstract
Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD) in children and confers improved survival, skeletal growth, heath-related quality of life, and neuropsychological development compared with dialysis. Kidney transplantation in children with ESRD results in 10-year patient survival exceeding 90%. Therefore, the long-term management of these patients is focused on maintaining quality of life and minimizing long-term side effects of immunosuppression. Optimal management of pediatric kidney transplant recipients includes preventing rejection and infection, identifying and reducing the cardiovascular and metabolic effects of long-term immunosuppressive therapy, supporting normal growth and development, and managing a smooth transition into adulthood.
摘要
肾移植是儿童终末期肾病（ESRD）的首选治疗方法，与透析相比，它能提高生存率、促进骨骼生长、改善健康相关生活质量以及促进神经心理发育。ESRD患儿肾移植后的10年患者生存率超过90%。因此，这些患者的长期管理重点是维持生活质量并将免疫抑制的长期副作用降至最低。小儿肾移植受者的最佳管理包括预防排斥反应和感染、识别并减轻长期免疫抑制治疗对心血管和代谢的影响、支持正常生长发育以及顺利过渡到成年期。
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Pediatr Nephrol. 2017 Dec;32(12):2331-2341. doi: 10.1007/s00467-017-3737-x. Epub 2017 Jul 25.
2
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Pediatr Transplant. 2017 Jun;21(4). doi: 10.1111/petr.12919. Epub 2017 Mar 31.
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