柠檬酸盐靶向果糖-1,6-二磷酸酶，构成了一种新兴的癌症治疗新方法。
Citrate targets FBPase and constitutes an emerging novel approach for cancer therapy.
作者信息
Icard Philippe, Fournel Ludovic, Coquerel Antoine, Gligorov Joseph, Alifano Marco, Lincet Hubert
机构信息
1Thoracic Surgery Department, Cochin Hospital, Normandy University of Caen, Unité Inserm 1199, Paris, France.
Thoracic Surgery Department, Cochin Hospital, Paris Descartes University, Unité Inserm 1007, 27 rue du Faubourg Saint Jacques, 75014 Paris, France.
出版信息
Cancer Cell Int. 2018 Nov 8;18:175. doi: 10.1186/s12935-018-0676-y. eCollection 2018.
Gao-Min Liu and Yao-Ming Zhang recently published a review entitled «Targeting FBPase is an emerging novel approach for cancer therapy» (Liu and Zhang in Cancer Cell Int 18:36, 2018). In this paper, the authors highlighted how the down regulation or inactivation of FBPase, a rate limiting enzyme of gluconeogenesis, can promote the Warburg effect and cancer growth. In contrast, activation of this enzyme demonstrates anti-cancer effects and may appear as emerging novel approach for cancer therapy. Among the potential activators of FBP listed by Liu and Zhang, citrate was surprisingly not mentioned although it is an activator of FBPase, also demonstrating various anti-cancer effects in pre-clinical studies. Thus, citrate should be tested as a new therapeutic strategy, in particular in clinical studies.
刘高敏和张耀明最近发表了一篇题为《靶向果糖-1,6-二磷酸酶是一种新兴的癌症治疗新方法》的综述（刘和张，《癌细胞国际》，2018年，第18卷，第36页）。在这篇论文中，作者强调了作为糖异生限速酶的果糖-1,6-二磷酸酶（FBPase）的下调或失活如何促进瓦伯格效应和癌症生长。相反，该酶的激活显示出抗癌作用，可能成为一种新兴的癌症治疗新方法。在刘和张列出的FBP潜在激活剂中，令人惊讶的是没有提到柠檬酸盐，尽管它是FBPase的激活剂，并且在临床前研究中也显示出各种抗癌作用。因此，柠檬酸盐应该作为一种新的治疗策略进行测试，特别是在临床研究中。
Zotero 插件