棕榈酸盐抑制肝脏糖酵解。果糖2,6 -二磷酸在葡萄糖/脂肪酸循环中的作用。
Palmitate inhibits liver glycolysis. Involvement of fructose 2,6-bisphosphate in the glucose/fatty acid cycle.
作者信息
Hue L, Maisin L, Rider M H
机构信息
Hormone and Metabolic Research Unit, Louvain University Medical School, Brussels, Belgium.
出版信息
Biochem J. 1988 Apr 15;251(2):541-5. doi: 10.1042/bj2510541.
Abstract
In hepatocytes from overnight-fasted rats incubated with glucose, palmitate decreased the production of lactate, the detritiation of [2-3H]- and [3-3H]-glucose, and the concentration of fructose 2,6-bisphosphate. Similarly, perfusion of hearts from fed rats with beta-hydroxybutyrate resulted in an inhibition of the detritiation of [3-3H]glucose and a fall in fructose 2,6-bisphosphate concentration. This fall could result from an increase in citrate (hepatocytes and heart) and sn-glycerol 3-bisphosphate concentration. It is suggested that a fall in fructose 2,6-bisphosphate concentration participates in the inhibition of glycolysis by fatty acids and ketone bodies.
摘要
在与葡萄糖一起孵育的过夜禁食大鼠的肝细胞中，棕榈酸酯降低了乳酸的产生、[2-³H]-和[3-³H]-葡萄糖的脱氚作用以及果糖2,6-二磷酸的浓度。同样，用β-羟基丁酸灌注喂食大鼠的心脏会导致[3-³H]葡萄糖脱氚作用的抑制以及果糖2,6-二磷酸浓度的下降。这种下降可能是由于柠檬酸（肝细胞和心脏）和sn-甘油3-二磷酸浓度的增加所致。有人提出，果糖2,6-二磷酸浓度的下降参与了脂肪酸和酮体对糖酵解的抑制作用。
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