健康的新加坡老年人在接种流感疫苗后，未表现出与年龄相关的体液低反应性，也没有出现浆母细胞生成减少的情况。
Healthy elderly Singaporeans show no age-related humoral hyporesponsiveness nor diminished plasmablast generation in response to influenza vaccine.
作者信息
Camous Xavier, Visan Lucian, Ying Crystal Tan Tze, Abel Brian, Nyunt Ma Shwe Zin, Narang Vipin, Poidinger Michael, Carre Christophe, Sesay Sanie, Bosco Nabil, Burdin Nicolas, Tambyah Paul Anantharajah, Pin Ng Tze, Larbi Anis
机构信息
1Biology of Aging Laboratory, Singapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore.
2Sanofi Pasteur, Research and Non-Clinical safety, Marcy L'Etoile, France.
出版信息
Immun Ageing. 2018 Nov 12;15:28. doi: 10.1186/s12979-018-0137-4. eCollection 2018.
ABSTRACT
Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influenza vaccination in older adults. Sustaining health in aging could be an important player in maintaining immune responses to influenza vaccination.
TRIAL REGISTRATION
NCT03266237. Registered 30 August 2017, https://clinicaltrials.gov/ct2/show/NCT03266237.
摘要
提高流感疫苗效力是减轻流感相关发病和死亡负担的当务之急。通过根据健康状况仔细挑选个体，我们发现老年人对流感疫苗接种有持续反应。在衰老过程中维持健康可能是维持对流感疫苗接种免疫反应的重要因素。
试验注册
NCT03266237。于2017年8月30日注册，https://clinicaltrials.gov/ct2/show/NCT03266237 。
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