Ognjenovic Ljubomir, Shumkovski Aleksandar, Gjoshev Stojan, Volchevski Goce, Trajkovski Gjorgji, Karadzov Zoran, Dzambaz Darko, Hadzi-Manchev Dragan, Hadzi-Manchev Todor, Petrushevska Gordana, Janevska Vesna, Janevski Vlado, Brzanov Nikola
University Clinic for Abdominal Surgery, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje, Republic of Macedonia.
Institute of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, Skopje, Republic of Macedonia.
Open Access Maced J Med Sci. 2018 Oct 12;6(10):1829-1832. doi: 10.3889/oamjms.2018.409. eCollection 2018 Oct 25.
The understanding of the etiopathogenesis of gastric carcinoma (GC) can be a base for development of new therapeutic methods to reduce mortality and to increase survival in patients with GC. The percentage of Epstein - Barr virus (EBV) positive gastric carcinomas is uncertain, and the etiologic importance of EBV in the pathogenesis of GC has still not been elucidated.
This study aimed to determine the percentage of EBV associated GC as well as to determine their clinicopathological characteristics.
The study included 80 patients with GC who were analysed for ethnicity, local growth of a tumour (T status), the presence of nodal metastases (N), the presence of distant metastases (M), stage of the disease and degree of carcinoma differentiation. For detection of EBV, immunostainings were performed on tumour tissue and the peripheral non-tumour gastric mucosa.
Positive immunostaining with an antibody against EBV was found in 19 (23.75%) of the 80 patients with gastric carcinomas. EBV immunostainings were significantly different in patients with or without metastasis and between patients of Macedonian and Albanian ethnicity (p < 0.0001, p < 0.009, respectively). EBV immunoexpression was significantly associated with the presence of distant metastases and with patients of Albanian ethnicity.
Association of EBV immunostainings with distant metastasis in patients with GC suggests the influence of EBV infection on the progression of gastric carcinoma. Due to scarce and doubtful literature data on EBV associated GC, further studies are necessary to determine the role of EBV regarding aetiology, treatment and prognosis in patients with EBV associated gastric carcinoma.
对胃癌发病机制的理解可为开发新的治疗方法奠定基础，以降低胃癌患者的死亡率并提高其生存率。爱泼斯坦-巴尔病毒（EBV）阳性胃癌的比例尚不确定，EBV在胃癌发病机制中的病因学重要性仍未阐明。
本研究旨在确定EBV相关胃癌的比例，并确定其临床病理特征。
该研究纳入80例胃癌患者，分析其种族、肿瘤局部生长情况（T分期）、有无淋巴结转移（N）、有无远处转移（M）、疾病分期及癌分化程度。为检测EBV，对肿瘤组织和外周非肿瘤胃黏膜进行免疫染色。
80例胃癌患者中，19例（23.75%）EBV抗体免疫染色呈阳性。有无转移的患者以及马其顿族和阿尔巴尼亚族患者的EBV免疫染色存在显著差异（分别为p < 0.0001，p < 0.009）。EBV免疫表达与远处转移的存在以及阿尔巴尼亚族患者显著相关。
胃癌患者中EBV免疫染色与远处转移相关，提示EBV感染对胃癌进展有影响。由于关于EBV相关胃癌的文献数据稀少且存在疑问，有必要进一步研究以确定EBV在EBV相关胃癌患者的病因、治疗和预后方面的作用。
