Yoshida Keimei, Saku Keita, Kamada Kazuhiro, Abe Kohtaro, Tanaka-Ishikawa Mariko, Tohyama Takeshi, Nishikawa Takuya, Kishi Takuya, Sunagawa Kenji, Tsutsui Hiroyuki
Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Department of Advanced Risk Stratification for Cardiovascular Diseases, Center for Disruptive Cardiovascular Medicine, Kyushu University, Fukuoka, Japan.
JACC Basic Transl Sci. 2018 Nov 12;3(5):657-671. doi: 10.1016/j.jacbts.2018.07.007. eCollection 2018 Oct.
This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension.
本研究旨在阐明电刺激迷走神经（VNS）对大鼠重度肺动脉高压模型的治疗作用。在一项病理生理学研究中，VNS显著恢复了自主神经平衡，降低了平均肺动脉压，减轻了肺血管重塑，并保留了右心室功能。在一项生存研究中，VNS在预防方案（SU5416注射后0至5周进行VNS）和治疗方案（5至10周进行VNS）中均显著提高了生存率。因此，VNS可能成为肺动脉高压的一种新型治疗策略。
