Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Pharmacotherapy, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
World J Pediatr. 2019 Feb;15(1):78-84. doi: 10.1007/s12519-018-0209-8. Epub 2018 Nov 19.
In this research the symptom improvement of attention-deficit hyperactivity disorder (ADHD) of children was assessed by oral vitamin D administration in Tabriz, Iran.
In this double-blind, randomized clinical trials, 96 children (2-18 years) were enrolled to placebo and vitamin D groups. Children took vitamin D pearl (50,000 IU/week) or placebo for 6 weeks. Children, who had the change in methylphenidate dosage and received any anticonvulsants and corticosteroids were excluded from the research. ADHD symptoms were diagnosed by Conners parent rating scale (CPRS) test at baseline and after intervention. ADHD Conners divided into inattention (IA), hyperactivity/impulsivity (H/I) and combination type (C) subscales. Vitamin D serum level was assessed at baseline and after 8 weeks in both groups.
The differences between CPRS and its subscales were not significant at baseline (P > 0.05). The Conners IA score was decreased in vitamin D group (P < 0.05; adjusted with age and baseline values). ADHD Conners and all subscale scores reduced remarkably after intervention in patients with insufficient level of vitamin D compared to placebo (P < 0.05).
Oral vitamin D improved ADHD symptoms with a particular effect on inattention symptoms. In addition, symptoms related to all subscales were improved remarkably in patients with insufficient level of vitamin D. Vitamin D treatment in children with ADHD could be considered due to the expand benefit of vitamin D in body.
本研究在伊朗大不里士评估了口服维生素 D 对儿童注意力缺陷多动障碍（ADHD）症状的改善作用。
在这项双盲、随机临床试验中，96 名（2-18 岁）儿童被纳入安慰剂和维生素 D 组。儿童每周服用维生素 D 丸（50000IU）或安慰剂 6 周。排除了改变哌醋甲酯剂量且接受任何抗惊厥药和皮质类固醇治疗的儿童。ADHD 症状在基线和干预后通过 Conners 父母评定量表（CPRS）测试进行诊断。ADHD Conners 量表分为注意力不集中（IA）、多动/冲动（H/I）和混合型（C）分量表。两组在基线和 8 周后均评估了维生素 D 血清水平。
CPRS 及其分量表在基线时无显著差异（P>0.05）。维生素 D 组的 Conners IA 评分降低（P<0.05；根据年龄和基线值进行调整）。与安慰剂相比，维生素 D 水平不足的患者在干预后 ADHD Conners 量表及其所有分量表评分显著降低（P<0.05）。
口服维生素 D 可改善 ADHD 症状，特别是对注意力不集中症状有特殊作用。此外，维生素 D 水平不足的患者所有分量表的症状均显著改善。鉴于维生素 D 在体内的广泛益处，可考虑对 ADHD 儿童进行维生素 D 治疗。
