Department of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, New York, USA.
Microbiology and Immunology Department, Harvard Medical School, Boston, Massachusetts, USA.
Equine Vet J. 2019 Jul;51(4):470-474. doi: 10.1111/evj.13046. Epub 2018 Dec 17.
Equus caballus papillomavirus 8, a recently discovered virus, has been reported to cause generalised papillomavirus in horses.
To describe a case in which multiple viral plaques, viral papillomas, squamous cell carcinoma (SCC) in situ and invasive squamous cell carcinoma (ISCC) were associated with EcPV8 in a horse.
Case report.
A 16-year-old mixed breed horse presented with dozens of raised crusted papular to nodular lesions over a course of 4 years. Masses had been surgically excised four times and cisplatin beads and emulsion were implanted on three different occasions; however new masses continue to develop in sites of previous masses as well as new sites.
Multiple viral plaques, viral papillomas, SCC in situ and ISCC, localised to the inguinal region, were diagnosed via histopathology. EcPV8 DNA was detected via PCR.
Since only a few cases have been reported, we do not know the incidence of EcPV8 nor how often it may be associated with SCC in situ or ISCC without further study.
This is the fourth reported case of viral papillomatosis in the context of an EcPV8 infection in a horse. This is the first case in which SCC has been associated with EcPV8.
最近发现的马源乳头瘤病毒 8 型（Equus caballus papillomavirus 8，EcPV8）已被报道可引起马匹的全身性乳头瘤病。
描述一例 EcPV8 感染马伴发多发性病毒斑块、病毒性乳头瘤、原位鳞状细胞癌（squamous cell carcinoma in situ，SCC）和浸润性鳞状细胞癌（invasive squamous cell carcinoma，ISCC）的病例。
病例报告。
一匹 16 岁的混种马在 4 年的时间里出现了数十个隆起的结痂丘疹样至结节状病变。肿块已被手术切除 4 次，曾 3 次植入顺铂珠和乳剂；但新的肿块仍在先前肿块和新的部位不断出现。
通过组织病理学诊断为多发性病毒斑块、病毒性乳头瘤、位于腹股沟区域的 SCC 原位和 ISCC。通过 PCR 检测到 EcPV8 DNA。
由于仅报道了少数几例病例，我们尚不清楚 EcPV8 的发病率，也不知道在进一步研究之前，EcPV8 与 SCC 原位或 ISCC 相关的频率。
这是第四例报告的 EcPV8 感染马伴发病毒性乳头瘤病的病例。这也是首例与 EcPV8 相关的 SCC 病例。
