Chen A, Ho Y S, Tu Y C, Shieh S D, Hung H W, Chou C T
Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Nephron. 1988;49(4):313-8. doi: 10.1159/000185082.
We describe 2 patients with immunoglobulin A (IgA) nephropathy in association with ankylosing spondylitis. Renal biopsy demonstrated mesangial proliferative glomerulonephritis with prominent IgA, C3c, and less intense properdin deposition in the glomeruli. Intraglomerular clumps of virus-like particles were also observed in the kidney sample from one patient (case 2), who had an abnormal liver function. Our findings support the hypothesis that here is a possible common pathogenesis responsible for the concurrence of both IgA nephropathy and ankylosing spondylitis.
我们描述了2例患有免疫球蛋白A（IgA）肾病并伴有强直性脊柱炎的患者。肾活检显示为系膜增生性肾小球肾炎，肾小球内有显著的IgA、C3c沉积，备解素沉积较弱。在其中一名肝功能异常的患者（病例2）的肾脏样本中还观察到肾小球内有病毒样颗粒团块。我们的研究结果支持这样一种假说，即IgA肾病和强直性脊柱炎并发可能存在共同的发病机制。
