强直性脊柱炎中的皮肤血管炎和IgA肾小球肾炎。
Cutaneous vasculitis and IgA glomerulonephritis in ankylosing spondylitis.
作者信息
Beauvais C, Kaplan G, Mougenot B, Michel C, Marinho E
机构信息
Department of Rheumatology, Hôpital Saint Antoine, Paris, France.
出版信息
Ann Rheum Dis. 1993 Jan;52(1):61-2. doi: 10.1136/ard.52.1.61.
Abstract
Two patients with ankylosing spondylitis were found to have IgA nephropathy and leucocytoclastic cutaneous vasculitis. Immunofluorescence showed perivascular deposition of IgA in the skin of one patient and in the mesangium of both patients. Such an association has been reported only once before. This supports the concept of abnormal IgA immune stimulation in the pathogenesis of ankylosing spondylitis.
摘要
两名强直性脊柱炎患者被发现患有IgA肾病和白细胞破碎性皮肤血管炎。免疫荧光显示，一名患者的皮肤和两名患者的系膜中有IgA血管周围沉积。这种关联此前仅被报道过一次。这支持了强直性脊柱炎发病机制中IgA免疫刺激异常的概念。
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