Gastrointestinal & Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, Iran.
Department of Microbiology, Islamic Azad University, Naein Branch, Naein, Iran.
Phytomedicine. 2018 Apr 1;43:28-36. doi: 10.1016/j.phymed.2018.03.043. Epub 2018 Mar 19.
Elevated levels of blood lipids are a major cause of atherosclerosis and consequently cardiovascular disease. Several studies used ginger as a lipid lowering agent.
The aim of the present systematic review and meta-analysis was to clarify the effect of ginger supplementation on lipid parameters.
PubMed, Scopus, Science Direct, ISI Web of Science and Google Scholar were systematically searched until May 2017 to find clinical trials which examined effect of ginger supplementation on level of lipid parameters in adult participants. Means for blood lipids and potential sources of heterogeneity were extracted. A subgroup analysis was applied to find out potential sources of inter-study heterogeneity.
A total of 12 trials (586 participants) were included in the meta-analysis. Pooled analysis suggested that ginger supplementation reduced triacylglycerol (TAG) (-17.59 mg/dl; 95% CI: -29.32 to -5.87) and low density lipoprotein cholesterol (LDL-C) (-4.90 mg/dl; 95% CI: -22.30 to -6.17). Ginger had no significant effect on total cholesterol (TC) (-5.13 mg/dl, 95% CI: -11.05 to 0.78; P = 0.089) and high density lipoprotein cholesterol (HDL-C) (2.18 mg/dl, 95% CI: -0.08 to 4.45; P = 0.059). As inter-study heterogeneity was high, studies were classified by ginger dosage. Stratified analysis showed a significant reduction in TC (-12.26 mg/dl; 95% CI: -22.37 to -2.16) and TAG (-38.42 mg/dl; 95% CI: -57.01 to -19.82) in studies which used ≤2 g/day of ginger. However, a similar significant effect was not observed in trials with >2 g/day of ginger. Neither studies which used ≤2 g/day nor trials which used >2 g/day of ginger showed significant changes in LDL-C or HDL-C.
The present systematic review and meta-analysis suggests that ginger had a favorable effect on TAG and LDL-C. Also, the result revealed that low dose of ginger (≤2 g/day) had greater lowering impact on TAG and TC. Further studies with large-scale and better design are needed to confirm this result.
血液中脂质水平升高是动脉粥样硬化和心血管疾病的主要原因。一些研究使用生姜作为降低血脂的药物。
本系统评价和荟萃分析的目的是阐明生姜补充剂对血脂参数的影响。
系统检索了 PubMed、Scopus、Science Direct、ISI Web of Science 和 Google Scholar，以查找至 2017 年 5 月检查生姜补充剂对成年参与者血脂参数水平影响的临床试验。提取血脂的均值和潜在的异质性来源。应用亚组分析来找出研究间异质性的潜在来源。
共有 12 项试验（586 名参与者）纳入荟萃分析。汇总分析表明，生姜补充剂可降低三酰甘油（TAG）（-17.59mg/dl；95%CI：-29.32 至-5.87）和低密度脂蛋白胆固醇（LDL-C）（-4.90mg/dl；95%CI：-22.30 至-6.17）。生姜对总胆固醇（TC）（-5.13mg/dl，95%CI：-11.05 至 0.78；P=0.089）和高密度脂蛋白胆固醇（HDL-C）（2.18mg/dl，95%CI：0.08 至 4.45；P=0.059）没有显著影响。由于研究间异质性较高，因此根据生姜剂量对研究进行了分类。分层分析表明，使用≤2g/天的生姜可显著降低 TC（-12.26mg/dl；95%CI：-22.37 至-2.16）和 TAG（-38.42mg/dl；95%CI：-57.01 至-19.82）。然而，在使用>2g/天的生姜的试验中未观察到类似的显著效果。使用≤2g/天的生姜或使用>2g/天的生姜的试验均未显示 LDL-C 或 HDL-C 的显著变化。
本系统评价和荟萃分析表明，生姜对 TAG 和 LDL-C 有有利影响。此外，结果表明，低剂量的生姜（≤2g/天）对 TAG 和 TC 的降低作用更大。需要进一步进行大规模、设计更好的研究来证实这一结果。
