ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Renal Registry Valencian Region, Generalitat Valencian, Spain.
Nephrology (Carlton). 2019 Oct;24(10):1064-1076. doi: 10.1111/nep.13531. Epub 2019 Apr 29.
To examine international time trends in the incidence of renal replacement therapy (RRT) for end-stage renal disease (ESRD) by primary renal disease (PRD).
Renal registries reporting on patients starting RRT per million population for ESRD by PRD from 2005 to 2014, were identified by internet search and literature review. The average annual percentage change (AAPC) with a 95% confidence interval (CI) of the time trends was computed using Joinpoint regression.
There was a significant decrease in the incidence of RRT for ESRD due to diabetes mellitus (DM) in Europe (AAPC = -0.9; 95%CI -1.3; -0.5) and to hypertension/renal vascular disease (HT/RVD) in Australia (AAPC = -1.8; 95%CI -3.3; -0.3), Canada (AAPC = -2.9; 95%CI -4.4; -1.5) and Europe (AAPC = -1.1; 95%CI -2.1; -0.0). A decrease or stabilization was observed for glomerulonephritis in all regions and for autosomal dominant polycystic kidney disease (ADPKD) in all regions except for Malaysia and the Republic of Korea. An increase of 5.2-16.3% was observed for DM, HT/RVD and ADPKD in Malaysia and the Republic of Korea.
Large international differences exist in the trends in incidence of RRT by primary renal disease. Mapping of these international trends is the first step in defining the causes and successful preventative measures of CKD.
通过主要肾脏疾病（PRD）检查终末期肾病（ESRD）接受肾脏替代治疗（RRT）的国际时间趋势。
通过互联网搜索和文献回顾，确定了 2005 年至 2014 年期间按 PRD 报告每百万人口 ESRD 接受 RRT 的患者的肾脏登记处。使用 Joinpoint 回归计算时间趋势的平均年百分比变化（AAPC）及其 95%置信区间（CI）。
在欧洲，由于糖尿病（DM）导致的 ESRD 接受 RRT 的发生率呈显著下降（AAPC=-0.9；95%CI-1.3；-0.5），在澳大利亚，由于高血压/肾血管疾病（HT/RVD）导致的发生率呈显著下降（AAPC=-1.8；95%CI-3.3；-0.3），在加拿大和欧洲，由于 HT/RVD 导致的发生率呈显著下降（AAPC=-2.9；95%CI-4.4；-1.5）和欧洲（AAPC=-1.1；95%CI-2.1；-0.0）。所有地区的肾小球肾炎以及除马来西亚和韩国以外的所有地区的常染色体显性多囊肾病（ADPKD）的发生率均下降或稳定。在马来西亚和韩国，DM、HT/RVD 和 ADPKD 的发生率分别增加了 5.2%-16.3%。
不同国家和地区之间 RRT 发生率的趋势存在较大差异。绘制这些国际趋势图是确定 CKD 病因和成功预防措施的第一步。
