School for Environment and Sustainability, University of Michigan, Ann Arbor, Michigan.
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan.
Am J Trop Med Hyg. 2019 Feb;100(2):374-376. doi: 10.4269/ajtmh.18-0173.
Small-scale farming may have large impacts on the selection and spread of antimicrobial resistance to humans. We conducted an observational study to evaluate antibiotic-resistant populations from poultry and humans in rural northwestern Esmeraldas, Ecuador. Our study site is a remote region with historically low resistance levels of third-generation antibiotics such cefotaxime (CTX), a clinically relevant antibiotic, in both poultry and humans. Our study revealed 1) high CTX resistance (66.1%) in farmed broiler chickens, 2) an increase in CTX resistance over time in backyard chicken not fed antibiotics (2.3-17.9%), and 3) identical sequences from human and chicken bacteria, suggesting a spillover event. These findings provide evidence that small-scale meat production operations have direct impacts on the spread and selection of clinically important antibiotics among underdeveloped settings.
小规模农业可能对人类对抗菌药物耐药性的选择和传播产生重大影响。我们进行了一项观察性研究，以评估厄瓜多尔西北部埃斯梅拉达斯农村地区禽畜和人类的抗生素耐药性种群。我们的研究地点是一个偏远地区，历史上禽畜对第三代抗生素（如头孢噻肟，一种临床相关的抗生素）的耐药水平较低。我们的研究结果显示：1）笼养肉鸡的头孢噻肟耐药性高（66.1%）；2）未服用抗生素的后院鸡的头孢噻肟耐药性随时间推移而增加（2.3-17.9%）；3）人类和鸡细菌的序列相同，提示有溢出事件。这些发现提供了证据，表明小规模肉类生产作业直接影响欠发达地区临床重要抗生素的传播和选择。
