Czirják L, Dankó K, Zeher M, Lukács K, Szegedi G
3rd Department of Medicine, University Medical School of Debrecen, Hungary.
Acta Med Hung. 1988;45(1):53-61.
Functions of monocytes from the peripheral blood of 23 patients with systemic sclerosis were investigated in vitro. The yeast phagocytosis, opsonized yeast phagocytosis and binding of EA (erythrocyte-antibody) particles were found to be normal. A depressed chemotactic response was demonstrated against a zymosan-activated, complement-derived chemotactic factor. In 12 cases, monocytes were cultured for 168 hours. By the 5th and 7th days, the initially depressed chemotactic activity of monocytes returned to normal as compared to controls. This fact supports the speculation that the decreased chemotaxis cannot be caused by an intrinsic abnormality of monocytes/macrophages in systemic sclerosis.
对23例系统性硬化症患者外周血单核细胞的功能进行了体外研究。发现酵母吞噬、调理酵母吞噬以及EA（红细胞-抗体）颗粒的结合均正常。针对酵母聚糖激活的补体衍生趋化因子，单核细胞的趋化反应表现出降低。在12例患者中，单核细胞培养168小时。到第5天和第7天，与对照组相比，单核细胞最初降低的趋化活性恢复正常。这一事实支持了以下推测，即系统性硬化症中趋化性降低并非由单核细胞/巨噬细胞的内在异常所致。
