Alcocer-Varela J, Martinez-Cordero E, Alarcon-Segovia D
Clin Exp Immunol. 1985 Mar;59(3):666-72.
Interleukin-1 (IL-1) is a monocyte derived factor that participates in immune regulation and in the regulation of fibroblast proliferation and collagen deposition. It therefore, seems particularly pertinent to study in scleroderma, a disorder of immune regulation where increased collagen deposition is a hallmark. The production of IL-1 by lipopolysaccharide stimulated monocytes from 18 untreated scleroderma patients was akin to that of their normal matched controls. However, the unstimulated monocytes from six of the 18 scleroderma patients released IL-1 activity spontaneously into their supernatants. All six patients with spontaneous IL-1 release had less than 5 years disease duration. The response to IL-1 by T lymphocytes from patients with scleroderma was low as compared to those from controls. The presence of spontaneous IL-1 production with decreased response to IL-1 in scleroderma may indicate an in vivo pre-activation of monocytes to produce this factor that might have a bearing in the pathogenesis of collagen deposition in scleroderma.
白细胞介素-1（IL-1）是一种由单核细胞产生的因子，参与免疫调节以及成纤维细胞增殖和胶原蛋白沉积的调节。因此，在硬皮病（一种免疫调节紊乱疾病，其特征是胶原蛋白沉积增加）中进行研究似乎特别有意义。18名未经治疗的硬皮病患者经脂多糖刺激的单核细胞产生IL-1的情况与正常对照者相似。然而，18名硬皮病患者中有6名未经刺激的单核细胞将IL-1活性自发释放到其上清液中。所有6名自发释放IL-1的患者病程均不到5年。与对照组相比，硬皮病患者的T淋巴细胞对IL-1的反应较低。硬皮病中存在自发产生IL-1且对IL-1反应降低的情况，这可能表明单核细胞在体内被预激活以产生该因子，这可能与硬皮病中胶原蛋白沉积的发病机制有关。
