一项关于甘油三酯和葡萄糖指数与非酒精性脂肪性肝病发病关系的纵向流行病学研究。
A longitudinal epidemiological study on the triglyceride and glucose index and the incident nonalcoholic fatty liver disease.
机构信息
Department of Pulmonology, Ningbo Yinzhou Second Hospital, Ningbo 1 Qianhe Road, Ningbo, 315192, China.
Department of Endocrinology, The Affiliated Hospital of Ningbo University School of Medicine, 247 Renmin Road, Ningbo, 315020, China.
出版信息
Lipids Health Dis. 2018 Nov 20;17(1):262. doi: 10.1186/s12944-018-0913-3.
BACKGROUND
Triglyceride and glucose (TyG) index and nonalcoholic fatty liver disease (NAFLD) both bave been related to insulin resistance (IR). The study aimed to investigate the longitudinal relationship between TyG index and NAFLD and to evaluate the ability of TyG, through comparing with the predictive value of other indexes, to identify individuals at risk for NAFLD.
METHODS
Four thousand and five hundred thirty nine subjects without NAFLD initially were followed up for 9 years. Cox regression models were used to analyze the risk factors of NAFLD.
RESULTS
Cox regression analyses indicated the TyG index was independently and positively associated with the risk of incident NAFLD. In receiver operating characteristic (ROC) curve analysis, the optimal cut-off level for TyG to predict incident NAFLD was 8.52 and the area under the ROC curve (AUC) was 0.76 (95% CI 0.74-0.77), which was larger than that of TG, ALT and FPG.
CONCLUSION
This study demonstrated that the elevation of the TyG index might predict increase risk for incident NAFLD and it may be suitable as a diagnostic criterion for NAFLD.
背景
甘油三酯和葡萄糖（TyG）指数与非酒精性脂肪性肝病（NAFLD）均与胰岛素抵抗（IR）有关。本研究旨在探讨 TyG 指数与 NAFLD 的纵向关系，并通过与其他指标的预测价值进行比较，评估 TyG 识别发生 NAFLD 风险个体的能力。
方法
最初有 4539 名无 NAFLD 的受试者进行了 9 年的随访。采用 Cox 回归模型分析 NAFLD 的危险因素。
结果
Cox 回归分析表明，TyG 指数与发生 NAFLD 的风险呈独立正相关。在受试者工作特征（ROC）曲线分析中，TyG 预测发生 NAFLD 的最佳截断值为 8.52，ROC 曲线下面积（AUC）为 0.76（95%CI 0.74-0.77），大于 TG、ALT 和 FPG。
结论
本研究表明，TyG 指数的升高可能预示着发生 NAFLD 的风险增加，可能适合作为 NAFLD 的诊断标准。
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