Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Department of Gastroenterology, Asahi University Hospital, Gifu, Japan.
Can J Gastroenterol Hepatol. 2019 Oct 7;2019:5121574. doi: 10.1155/2019/5121574. eCollection 2019.
The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) and fasting plasma glucose (FPG), is reported as a surrogate index for insulin resistance. Although a cross-sectional study revealed the association between the TyG-index and the prevalence of nonalcoholic fatty liver disease (NAFLD), few studies have investigated the association between the TyG-index and incident NAFLD. Here we investigated whether the TyG-index can be used to predict incident NAFLD.
This historical cohort study included 16,093 apparently healthy Japanese individuals. The TyG-index was calculated by the established formula: TyG = Ln [TG (mg/dl) × FPG (mg/dl)/2]. Fatty liver was diagnosed based on the subjects' abdominal ultrasonography results. We divided the subjects into tertiles according to the levels of TyG-index. Hazard ratios (HRs) of the TyG-index for incident NAFLD were calculated by a Cox proportional hazards regression model.
During the observation period, 27.4% of the men and 11.0% of the women developed NAFLD. The highest TyG-index tertile (men, 8.48 ≤ TyG and women, 7.97 ≤ TyG) (adjusted HR 1.67, 95% CI 1.44-1.94, < 0.001 in the men and 2.06, 1.59-2.70, < 0.001 in the women) and the middle TyG-index tertile (men, 8.00 < TyG ≤ 8.48 and women, 7.53 <TyG ≤7.97) (1.33, 1.15-1.54, < 0.001 in the men and 1.52, 1.16-2.01, < 0.001 in the women) presented a significantly higher risk of incident NAFLD compared to the lowest TyG-index tertile (men, TyG < 8.00 and women, TyG < 7.53).
Our findings demonstrate that the TyG-index is significantly associated with incident NAFLD.
甘油三酯和葡萄糖指数（TyG）定义为甘油三酯（TG）和空腹血浆葡萄糖（FPG）的乘积，被报道为胰岛素抵抗的替代指标。尽管一项横断面研究显示 TyG 指数与非酒精性脂肪肝（NAFLD）的患病率之间存在关联，但很少有研究调查 TyG 指数与新发 NAFLD 之间的关系。在这里，我们研究了 TyG 指数是否可用于预测新发 NAFLD。
本历史队列研究纳入了 16093 名日本体检人群。TyG 指数通过以下公式计算得出：TyG = Ln [TG（mg/dL）× FPG（mg/dL）/2]。根据腹部超声检查结果诊断脂肪肝。根据 TyG 指数的水平将受试者分为三分位组。通过 Cox 比例风险回归模型计算 TyG 指数对新发 NAFLD 的风险比（HR）。
在观察期间，27.4%的男性和 11.0%的女性发生了 NAFLD。TyG 指数最高的三分位组（男性 TyG 指数为 8.48≤，女性 TyG 指数为 7.97≤）（校正 HR 1.67，95%CI 1.44-1.94，男性<0.001，女性 2.06，1.59-2.70，女性<0.001）和 TyG 指数中等的三分位组（男性 TyG 指数为 8.00< TyG≤8.48，女性 TyG 指数为 7.53< TyG≤7.97）（男性 1.33，1.15-1.54，男性<0.001，女性 1.52，1.16-2.01，女性<0.001）与 TyG 指数最低的三分位组（男性 TyG<8.00，女性 TyG<7.53）相比，发生新发 NAFLD 的风险显著更高。
我们的研究结果表明，TyG 指数与新发 NAFLD 显著相关。
