Tormoehlen Laura M, Rusyniak Daniel E
Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Emergency Medicine, Division of Medical Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States.
Department of Emergency Medicine, Division of Medical Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States.
Handb Clin Neurol. 2018;157:663-675. doi: 10.1016/B978-0-444-64074-1.00039-2.
The clinical manifestation of drug-induced abnormalities in thermoregulation occurs across a variety of drug mechanisms. The aim of this chapter is to review two of the most common drug-induced hyperthermic states, serotonin syndrome and neuroleptic malignant syndrome. Clinical features, pathophysiology, and treatment strategies will be discussed, in addition to differentiating between these two syndromes and differentiating them from other hyperthermic or febrile syndromes. Our goal is to both review the current literature and to provide a practical guide to identification and treatment of these potentially life-threatening illnesses. The diagnostic and treatment recommendations made by us, and by other authors, are likely to change with a better understanding of the pathophysiology of these syndromes.
药物引起的体温调节异常的临床表现涉及多种药物作用机制。本章旨在综述两种最常见的药物引起的高热状态，即5-羟色胺综合征和抗精神病药恶性综合征。除了区分这两种综合征以及将它们与其他高热或发热综合征区分开来外，还将讨论其临床特征、病理生理学和治疗策略。我们的目标是既回顾当前的文献，又提供一份识别和治疗这些潜在危及生命疾病的实用指南。随着对这些综合征病理生理学的更好理解，我们以及其他作者提出的诊断和治疗建议可能会发生变化。
