Martins José Diogo, Morais Passos Rita, Pardal Nuno, Carvoeiro Ana Catarina, Correia Fernando
Internal Medicine, Unidade Local de Saúde do Alto Minho, Viana do Castelo, PRT.
Medical School, Universidade do Minho, Braga, PRT.
Cureus. 2024 Nov 18;16(11):e73963. doi: 10.7759/cureus.73963. eCollection 2024 Nov.
Serotonin syndrome (SS) is a potentially life-threatening condition caused by excessive serotonergic activity, often due to drug interactions. It classically manifests with autonomic and neuromuscular hyperactivity and by mental status changes that might include restlessness, delirium, and agitation. We present a case of a 76-year-old patient with Parkinson's disease with SS triggered by interaction between rasagiline and buspirone. He presented with altered mental status, hyperreflexia, and muscle rigidity. Due to the severity of symptoms, he was early admitted to the ICU, and his clinical condition improved after discontinuation of serotonergic agents and supportive care. In SS, a high index of suspicion is fundamental, so early treatment is implemented.
血清素综合征（SS）是一种由血清素能活性过高引起的潜在危及生命的病症，通常源于药物相互作用。其典型表现为自主神经和神经肌肉活动亢进以及精神状态改变，可能包括烦躁不安、谵妄和激越。我们报告一例76岁帕金森病患者，因雷沙吉兰与丁螺环酮相互作用引发血清素综合征。他出现了精神状态改变、反射亢进和肌肉强直。由于症状严重，他早期被收入重症监护病房，停用血清素能药物并给予支持治疗后临床状况有所改善。在血清素综合征中，高度的怀疑指数至关重要，因此需尽早进行治疗。
