Temiz Selami Aykut, Özer İlkay, Ataseven Arzu, Fındık Sıddıka
Department of Dermatology, Necmettin Erbakan University School of Medicine, Konya, Turkey.
Department of Pathology, Necmettin Erbakan University School of Medicine, Konya, Turkey.
Turk J Gastroenterol. 2019 Mar;30(3):299-302. doi: 10.5152/tjg.2018.17887.
Fixed drug eruption (FDE) is a type of drug reaction characterized by localized erythema, hyperpigmentation, and bullous at the same site(s), generally observed following every intake of a causative drug. Delayed-type cellular hypersensitivity (Type IVC) is considered to play a role in FDE etiology. Several antibiotics, barbiturates, oral contraceptives, nonsteroidal anti-inflammatory drugs, laxative-containing phenolphthalein, metronidazole, and quinine are known to be the primary drugs responsible for FDE. Bullous FDE, on the other hand, is a relatively rare form of FDE. Hepatitis B is a significant worldwide health problem, and entecavir is a common nucleoside (deoxyguanosine) analog used for treating hepatitis B; however, it has various side effects, such as lactic acidosis, myalgia, azotemia, hypophosphatemia, headache, diarrhea, pancreatitis, and neuropathy, and, in rare cases, cutaneous drug eruption. Our aim is to present a case of entecavir-associated bullous drug reaction, which has not been reported in the literature. Furthermore, we performed a review of literature to compile previously reported entecavir-associated drug reactions.
固定性药疹（FDE）是一种药物反应类型，其特征为在相同部位出现局限性红斑、色素沉着和水疱，通常在每次摄入致病药物后出现。迟发型细胞超敏反应（IVC型）被认为在FDE的病因中起作用。已知几种抗生素、巴比妥类药物、口服避孕药、非甾体抗炎药、含酚酞的泻药、甲硝唑和奎宁是导致FDE的主要药物。另一方面，大疱性FDE是FDE的一种相对罕见的形式。乙型肝炎是一个重大的全球健康问题，恩替卡韦是一种用于治疗乙型肝炎的常见核苷（脱氧鸟苷）类似物；然而，它有各种副作用，如乳酸性酸中毒、肌痛、氮质血症、低磷血症、头痛、腹泻、胰腺炎和神经病变，并且在罕见情况下会出现皮肤药物疹。我们的目的是报告一例恩替卡韦相关的大疱性药物反应病例，该病例在文献中尚未见报道。此外，我们对文献进行了综述，以汇总先前报道的恩替卡韦相关药物反应。
